替米沙坦联合用药治疗老年高血压的临床研究(1)
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[摘要] 目的：探讨替米沙坦联合吲达帕胺或左旋氨氯地平治疗老年高血压的疗效及安全性。方法：选择78例老年原发性高血压患者随机分为两组，替米沙坦+吲达帕胺组(吲达帕胺组)和替米沙坦+左旋氨氯地平组(左旋氨氯地平组)进行治疗，疗程8周。结果：第2周末，吲达帕胺组和左旋氨氯地平组的降压达标率分别为61.5%和48.7%，两组比较，差异有统计学意义 (P<0.05)。第8周末，两组降压达标率分别为71.8%和74.4%，降压总有效率分别为82.1%和84.6%，两组比较，差异均无统计学意义 (P>0.05)。结论：替米沙坦联合吲达帕胺或左旋氨氯地平能有效降低老年高血压患者的血压水平，耐受性好，故这种方法值得推广应用。
[关键词] 高血压；老年患者；替米沙坦
[中图分类号] R544.1[文献标识码]B [文章编号]1673-7210(2010)10(b)-052-03
Clinical research of combinative remedy with Telmisartan on aged patients with hypertension
TAN Bifeng1, YANG Tianlun1, HUANG Youliang2，YU Qunjun2， YU Jiaxian2, LU Sheng2
(1.Department of Cardiology, the Xiangya Hospital of Central South University, Changsha 410008, China; 2. Department of Cardiology, the Third People′s Hospital of Huaihua City Affiliated to Huaihua Medicial College, Huaihua 418000, China )
[Abstract] Objective: To evaluate the efficacy and safety of Telmisartan combined with Indapamide or Levamlodipine on aged patients with hypertension. Methods: 78 aged patients with essential hypertension were chosen casually and divided into two groups, one was treated with Telmisartan and Indapamide (Indapamide group), the other was treated with Telmisartan and Levamlodipine (Levamlodipine group). The course of treatment was 8 weeks. Results: After 2 weeks′ treatment, the reaching standard rate was 61.5% of Indapamide group and 48.7% of Levamlodipine group, the differences was statically significant between two groups (P<0.05). After 8 weeks′ treatment, the reaching standard rate was 71.8% of Indapamide group and 74.4% of Levamlodipine group, and the effective rate were 82.1% and 84.6% respectively, there were no significant differences between two groups (P>0.05). Conclusion: Telmisartan combined with Indapamide or Levamlodipine can effectively reduce the blood pressure of aged patients with hypertension, and the tolerance is good, so this method is worth popularizing.
[Key words] Hypertension; Aged patients; Telmisartan
高血压是老年人的常见病和多发病，也是患者脑血管意外、心力衰竭及致死、致残的主要危险因素之一。截止2004年底，我国60岁以上老年人口已达1.43亿，占总人口的10.97%。随着人口老龄化趋势的加快，老年人的高血压患病率逐年增长。在高血压的治疗中，无论选用哪种药物，单药只能使有限的患者血压达标，大部分患者都需要通过联合治疗方能达到目标血压，联合治疗降压效果更好，达标率更高，不良反应越少，依从性越高[1]。在我国老年高血压人群中，血管紧张素Ⅱ受体拮抗剂与钙通道阻滞剂联用方案的疗效是否优于血管紧张素Ⅱ受体拮抗剂与利尿剂联用方案尚不明确 ......
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