厄贝沙坦在改善老年高血压患者心肾功能中的临床应用价值(1)
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[摘要] 目的：探讨厄贝沙坦对老年高血压患者心肾功能的改善作用。方法：对收治的老年高血压患者采用厄贝沙坦(75 mg/d)治疗10～12个月，并探讨其在改善患者心肾功能中的作用。结果：56例老年高血压患者经过厄贝沙坦治疗后，其收缩压(126.7±7.9)和舒张压(81.2±6.5)mm Hg，均较治疗前明显降低(t=6.78，P=0.032)；左室重量(191.2±40.1)g较治疗前明显减少(t=7.24、6.91；P=0.029、0.025)，左室重量指数(112.3±21.3)g/m2较治疗前明显减小(t=6.91，P=0.029)；肾动脉管壁厚度明显变薄，肾动脉内径明显增大(t=6.35、7.76；P=0.021，0.019)；血β2-MG(2.5±0.6)，尿β2-MG(0.15±0.02)水平均较治疗前明显降低(t=6.23、7.49；P=0.022，0.017)。结论：对于老年高血压病患者来说，厄贝沙坦既能降压，又能减轻或逆转心肾等器官损伤，值得临床推广使用。
[关键词] 厄贝沙坦；老年高血压；心肾功能
[中图分类号] R544.1 [文献标识码]A[文章编号]1673-7210(2011)04(b)-071-02
Clinical application of Irbesartan in improving heart and kidney function in elderly hypertensive patients
LEI Hua, HUANG Jianpeng, PANG Fangyu
Tangxia Hospital of Dongguan City, Dongguan 523721, China
[Abstract] Objective: To investigate the effects of Irbesartan in elderly hypertensive patients with heart and kidney function improvement. Methods: In this paper, the elderly patients with hypertension were treated with Irbesartan (75 mg/d) for 10-12 months, and to explore its function in improving the role of heart and kidney patients. Results: 56 cases with elderly hypertensive were treated with Irbesartan, the systolic and diastolic blood pressure were significantly lower than those before treatment (t=6.78, P=0.032). LVM and LVMI were significantly reduced than those before treatment (t=7.24, 6.91; P=0.029, 0.025). The renal artery wall was significantly thinner, and renal artery diameter was increased significantly(t=6.35, 7.76; P=0.021, 0.019) than before treatment. Blood and urine β2-MG level was significantly lower than before treatment (t=6.23, 7.49; P=0.022, 0.017). Conclusion: For elderly patients with hypertension, Irbesartan can lower blood pressure, and reduce or reverse the damage the kidneys and other organs. So it is worthy of clinical use.
[Key words] Irbesartan; Elderly hypertensive; Heart and kidney function
高血压是终末期肾病的一个主要原因，高血压可引起进行性肾小球硬化，使肾功能受损，因此对于高血压早期肾功能损害的认识显得尤为重要。由于老年人多病、病程长、常同时使用多种药物，对老年高血压病患者来说，除了要最大限度地降低其死亡和病残的危险外，还要考虑药物对机体的毒副作用 ......
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