孕妇体重、C反应蛋白与孕期血糖的相关性研究(1)
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[摘要] 目的：探讨孕妇体重、C反应蛋白(CRP)与孕期血糖的相关性。方法： 486例孕妇按体重指数(BMI)分为正常组、超重组和肥胖组；按CRP浓度分为低浓度组、中浓度组和高浓度组，对三组孕妇进行血糖检测。结果：FPG异常、GCT异常、OGTT异常和GDM均随孕妇体重升高、CRP浓度升高呈增加趋势，组间比较差异均有高度统计学意义(均P<0.01)；孕前BMI与CRP呈正相关(r=0.66，P<0.01)。结论：孕妇体重、CRP与孕期血糖密切相关，孕妇体重与CRP呈明显正相关。
[关键词] 孕妇体重；C反应蛋白；孕期血糖
[中图分类号] R714 [文献标识码] A [文章编号] 1673-7210(2011)06(c)-053-02
Correlation research between pregnant women weight, C-reactive protein and the blood glucose during pregnancy
TENG Xiaodong
Heishanzui Township Central Hospital of Fengning Man Autonomous County, Hebei Province, Fengning 068353, China
[Abstract] Objective: To investigate the correlationship between pregnant women weight, C-reactive protein and the blood glucose during pregnancy. Methods: 486 cases of pregnant women were divided into normal, overweight and obese groups by body mass index (BMI), they were divided into low concentration group, middle concentration and high concentration group by CRP concentration. Pregnant women blood glucose were tested of three groups. Results: Abnormal FPG, abnormal GCT, abnormal OGTT and GDM showed an increasing trend with increasing of pregnant women weight and CRP concentration, groups compared showed significant differences (all P<0.01); pregnant women pre-pregnancy BMI was positively correlated with CRP (r=0.66, P<0.01). Conclusion: Pregnant women weight and CRP are closely correlated with blood glucose during pregnancy, pregnant women weight was positively correlated with CRP.
[Key words] Pregnant women weight; C-reactive protein; Pregnancy blood glucose
近年来，随着人们生活方式、饮食习惯的改变和孕期检查的普及，孕妇孕期血糖异常升高日益多见，易发展形成妊娠期糖尿病(GDM)，母婴并发症、围生期死亡率大大增高，严重危害母婴健康[1]。本文对我院近年来收治的孕妇分别按孕妇体重指数(BMI)、C反应蛋白(CRP)不同分组，探讨孕妇体重、C反应蛋白与孕期血糖的相关性，现报道如下：
1 资料与方法
1.1 一般资料
选取2006年6月～2010年6月在我院住院分娩并定期孕检的孕妇486例，年龄22～39岁，平均(27.8±2.2)岁。所有孕妇均足月单胎，孕前检查均无糖尿病史，近期未使用皮质激素，无糖耐量异常、孕期肿瘤、急性感染及其他妊娠合并症和并发症。
1.2 方法
参照中国肥胖问题荟萃分析协作工作组建议，按孕妇孕前BMI分为正常组(18.5 kg/m2≤BMI<23 kg/m2)、超重组(23 kg/m2≤BMI<25 kg/m2)、肥胖组(BMI≥25 kg/m2)[2]；孕10～14周时清晨禁食12 h空腹取肘静脉血，采用全血快速胶体金双抗体夹心法检测孕妇CRP，按浓度分为低浓度组(CRP≤2.0 mg/L)、中浓度组(2.0 mg/L
1.3 血糖检测和判定标准
孕10～14周时检测空腹血糖(FPG)，≥5.8 mmol/L即为异常连续2次或2次以上则诊断为GDM；孕24～28周糖筛查(GCT) ......
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