中药外敷联合硫酸吗啡缓释片治疗转移性骨肿瘤癌性疼痛临床研究(1)
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[摘要] 目的：探讨中药外用联合硫酸吗啡缓释片治疗转移性骨肿瘤癌痛的止痛效果。方法：将我院收治的转移性骨肿瘤癌痛患者68例随机分为观察组(34例)和对照组(34例)。两组患者均给予硫酸吗啡缓释片必要时口服，观察组在此基础上加用中药外敷止痛。比较两组止痛有效率及硫酸吗啡缓释片使用频率及剂量。结果：观察组缓解率为76.47%(26/34)，高于对照组的50.00%(17/34)，差异有统计学意义(P<0.05)。观察组硫酸吗啡缓释片使用频率及剂量分别为(7±3)次/周、(30±10)mg/d，均低于对照组的(15±5)次/周、(60±15)mg/d，差异有统计学意义(P<0.05)。结论：中药外敷联合硫酸吗啡缓释片治疗转移性骨肿瘤癌痛止痛效果明显优于单用硫酸吗啡缓释片，可提高患者存活期间的生存质量，可在临床推广应用。
[关键词] 中药；硫酸吗啡缓释片；转移性骨肿瘤；癌性疼痛
[中图分类号] R738.1 [文献标识码] A [文章编号] 1673-7210(2011)11(b)-107-02
Clinical research on external application of Chinese medicine combined with Morphine Sulfate Sustained Release Tablets in the treatment of cancerous pain of metastatic tumor of bone
LIU Xinping
Department of Medical Oncology, the South District of Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 102618, China
[Abstract] Objective: To study the acesodyne effect of the external application of Chinese medicine combined with Morphine Sulfate Sustained Release Tablets in the treatment of cancerous pain of metastatic tumor of bone. Methods: 68 patients with cancerous pain of metastatic tumor of bone in our hospital were divided into observation group (34 cases) and control group (34 cases). All patients in both groups were treated by Morphine Sulfate Sustained Release Tablets when needed, observation group were treated by external application of Chinese medicine based on that. And then the effective rates, applied frequency and dosage of the Morphine Sulfate Sustained Release Tablets of the two groups were compared. Results: The remission rate of the observation group was 76.47% (26/34), which was higher than that of the control group [50.00% (17/34)], and showed asignificant difference (P<0.05). The applied frequency and dosage of the Morphine Sulfate Sustained Release Tablets were (7±3) times a week, (30±10) mg a day, which was lower than that of the control group [(15±5) times a week, (60±15) mg a day], and showed asignificant difference (P<0 ......
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