消化道肿瘤化疗前后血浆D-二聚体水平的变化(1)
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[摘要] 目的：探讨消化道肿瘤患者血浆D-二聚体水平与化疗疗效及临床分期的关系。方法：80例入组的消化道肿瘤患者(其中，男48例，女32例)，采用免疫散射比浊方法、日本CA-7000全自动监测仪测定化疗前后血浆D-二聚体的含量。结果：化疗前消化道肿瘤进展期(Ⅲ、Ⅳ期)D-二聚体含量分别为(1.15±0.48)、(2.32±0.77)mg/L；早期(Ⅱ期)D-二聚体含量为(0.28±0.09)mg/L；三者间比较，D-二聚体差异有高度统计学意义(P<0.01)。化疗后，有效(CR+PR)37例，稳定(SD)25例、进展(PD)18例，治疗后D-二聚体水平含量分别为(0.79±0.24)、(1.82±0.27)、(5.28±0.56)mg/L；且进展期(Ⅲ、Ⅳ期)化疗后有效组(CR+PR)D-二聚体含量显著低于化疗前，差异有统计学意义(P<0.05)；进展组明显高于化疗前(P<0.05)；稳定组(SD)差异无统计学意义(P>0.05)。结论：血浆D-二聚体水平高低可作为消化道肿瘤观察临床分期、判断预后及化疗疗效的一个临床指标。
[关键词] 消化道肿瘤；D-二聚体；化疗；预后
[中图分类号] R735 [文献标识码] B [文章编号] 1673-7210(2011)11(c)-096-03
Study on the change of blood plasma D-dimer in digestive system cancer patients before and after chemotherapy
CAI Yunyun, TAO Li, WU Haixia, XIAO mi, ZHENG Hong*
Department of Chemotherapy, Shanghai Minhang Branch of Fudan University Cancer Hospital, Shanghai 200316, China
[Abstract] Objective: To evaluate the relation and predictive value of D-dimer levels with chemotherapy response in digestive cancer patients. Methods: 80 patients were evaluated and analysed (48 cases were male, 32 cases were female); 77 patients were at the advanced stage. D-dimer levels were measured before and after 2 cycles of combination chemotherapy. D-dimer was measured with immune nephelometry in Sysmex CA-7000 automatic analyzer. Results: D-dimer levels of the Ⅲ and Ⅳ stage digests cancer were (1.15±0.48), (1.98±0.77) mg/L respectively, Ⅱ stage digests cancer was (0.28±0.09) mg/L, there were significant differences among the D-dimer levels of three stages (P<0.01). After chemotherapy, 37 cases were complete response (CR) and partial response (PR), 25 cases were stable disease (SD), 18 cases progressive disease (PD), D-dimer levels were (0.79±0.24), (1.82±0.27), (5.28±0.56) mg/L respectively after treatment. After chemotherapy, the D-dimer levels of availability group (PR+CR) in the Ⅲ and Ⅳ stage were lower than before chemotherapy (P<0.05), and the progressive disease group was higher than before chemotherapy (P<0.05), and not changed in SD patients (P>0.05). Conclusion: Levels of plasma D-dimer can be considered as a potential predictor in observing the clinical stages, prognosis judging and chemotherapy effect of metastatic gastric cancer ......
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