胰腺癌CT增强程度与微血管密度、血管内皮生长因子表达的相关性分析(1)
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[摘要] 目的：探讨胰腺癌病灶CT增强与瘤体实质微血管密度(MVD)、血管内皮生长因子(VEGF)表达的相关性。方法：选择经手术切除的胰腺癌患者38例，术前均行CT增强扫描；分析胰腺癌病灶CT增强情况与瘤体实质MVD、VEGF表达的相关性。结果：胰腺癌CT胰实质期瘤体强化程度、形式与其恶性度高低呈显著负相关(r=-0.695，P<0.001)，与瘤体实质细胞处MVD计数显著负相关(r=-0.768，P<0.001)；胰腺癌的病理分级与瘤体实质细胞处MVD计数呈正相关(r=0.395，P<0.05)，而与VEGF表达无关(r=-0.290，P>0.05)。结论：胰腺癌病灶CT增强程度可有效反映瘤体实质MVD、VEGF的表达情况，能反映瘤体实质微血管形成情况。
[关键词] 计算机体层摄影术；胰腺癌；血管形成
[中图分类号] R735.9 [文献标识码] B [文章编号] 1673-7210(2011)11(c)-109-02
The relationship between Enhancement patterns of CT and expression of microvessel density and vascular endothelial growth factor
HU Yueshu, FU Feixian
Department of General Surgery, the Central Hospital of Yiyang City, Hu′nan Provience, Yiyang 413000, China
[Abstract] Objective: To evaluate the correlation between parameters of computed tomography (CT) enhancement and microvessel density (MVD) or expression of vascular endothelial growth factor (VEGF) of the tumor in patients with pancreatic cancer. Methods: 38 patients with pancreatic cancer who underwent dynamic CT and tumor resection were studied. The relationships between the perfusion parameters and MVD or expression of VEGF of the tumor were analyzed. Results: CT enhancement of tumor was inversely proportional with the m alignant degree of pancreatic carcinoma (r=-0.695, P<0.001) and the MVD counting in the hot spot areas of tumor (r=-0.768, P<0.001). The pathological grade positively correlated with MVD (r=0.395, P<0.05), and had no correlation with VEGF expression (r=-0.290, P>0.05). Conclusion: Parameters of CT enhancement can reflect the expression of MVD and VEGF in the tumor effectively, and is an indicator for evaluating angiogenesis.
[Key words] Computer tomography; Pancreatic cancer; Angiogenesis
胰腺癌在我国和全世界的发病率及死亡率不断上升，严重危害人们的健康[1]。胰腺癌很容易向周围组织侵袭、扩散，这与胰腺癌血管生成有密切关系[2]。肿瘤血管生成是肿瘤组织向其周围组织生成毛细血管的过程，并且血管生成是恶性肿瘤生长和转移的基础[3]。目前研究认为肿瘤组织的微血管密度(microvessel density，MVD)可评价肿瘤血管生成程度，也可较好地于术前评价胰腺癌的恶性程度，有助于临床患者术后的预后评估。此外血管内皮生长因子(vascular endothelial growth factor，VEGF)在肿瘤血管生成的发生和侵袭过程中有重要作用，对判断肿瘤预后有重要意义[2]。本研究旨在通过研究胰腺癌病灶CT增强与瘤体实质处MVD及VEGF表达的相关性，为术前合理评价胰腺癌的恶性程度及选择合适的治疗方案提供影像学依据。
1 资料与方法
1.1 一般资料 ......
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