原发性高血压患者血浆脂联素水平与胰岛素抵抗及高敏C反应蛋白的关系(1)
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[摘要] 目的：检测原发性高血压(EHP)患者血浆脂联素水平，探讨其与胰岛素抵抗及高敏C反应蛋白(hs-CRP)的关系。方法：选取原发性高血压患者(EHP组)102例及血压正常者(NT组)80例，测定空腹血浆脂联素浓度、血清胰岛素水平及hs-CRP，稳态模型法(HOMA)计算胰岛素抵抗指数(HOMA-IR)。结果：①EHP组的脂联素水平[(6.82±3.41)mg/L]明显低于NT组[(9.51±2.42)mg/L]，差异有高度统计学意义(P<0.01)。②EHP组的hs-CRP水平[(9.42±2.30)mg/L]明显高于NT组[(4.68±1.73)mg/L]，差异有高度统计学意义(P<0.01)。③HOMA-IR随血压水平升高而升高，2级及3级EHP组与NT组比较差异有统计学意义(P<0.05)。④相关分析显示脂联素与收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、腰围(WC)、HOMA-IR、hs-CRP之间存在负相关。脂联素、BMI、hs-CRP、HOMA-IR为影响血压的独立因素。结论：①原发性高血压患者血浆脂联素水平较血压正常者明显降低，且其hs-CRP升高，存在胰岛素抵抗。②血压与脂联素、BMI、hs-CRP、HOMA-IR之间存在独立的相关性。
[关键词] 原发性高血压；脂联素；胰岛素抵抗；高敏C反应蛋白
[中图分类号] R544.1 [文献标识码] A [文章编号] 1673-7210(2011)12(a)-018-03
Relationship of plasma adiponectin levels, Insulin resistance and hs-CRP in patients with essential hypertension
JIANG Han1, XI Hui2, LU Tian3*, HU Hongyan3
1. Department of Cardiology, Dalian Port Hospital, Liaoning Province, Dalian 116001, China; 2.Clinical Medicine, China Medical University seven year system, Liaoning Province, Dalian 116001, China; 3.VIP Department, the First Affiliated Hospital of Dalian Medical University, Liaoning Province, Dalian 116001, China
[Abstract] Objective: To investigate the correlation between plasma adiponectin, Insulin resistance and hs-CRP by detecting plasma adiponectin levels in essential hypertensive (EHP) patients. Methods: 102 patients were enrolled in the EHP group, 80 patients were enrolled in the NT group. Fasting plasma adiponectin level, insulin, hypersensitive C-reactive (hs-CRP) were measured in each patient. HOM-A-IR was used as an insulin resistant index. Results: ①The adiponectin level in EHP group [(6.82±3.41)mg/L] was significantly lower than that in NT group [(9.51±2.42)mg/L] (P<0.01). ②The hs-CRP level in EHP group [(9.42±2.30)mg/L] was significantly higher than that in NT group [(4 ......
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