左氧氟沙星治疗支原体肺炎30例临床观察(1)
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[摘要] 目的：探讨治疗支原体肺炎的有效方法，合理选择抗生素。方法：收集整理2009年1月～2010年12月我院确诊为支原体肺炎的52例患者的临床资料，进行回顾性分析，阿奇霉素组22例，左氧氟沙星组30例，分析阿奇霉素和左氧氟沙星在临床应用中的临床疗效。结果：比较发现阿奇霉素的耐药增加，阿奇霉素组体温下降趋缓，左氧氟沙星组体温下降明显，两组体温下降情况比较，差异有统计学意义(P<0.05)。阿奇霉素组肺部影像吸收总有效率为63.64%，左氧氟沙星组为100.00%，两组比较差异有高度统计学意义(χ2=15.432，P<0.01)。结论：左氧氟沙星治疗支原体肺炎疗效优于阿奇霉素，值得临床推广。
[关键词] 支原体肺炎；抗生素；左氧氟沙星；阿奇霉素
[中图分类号] R563.1 [文献标识码] A [文章编号] 1673-7210(2011)12(a)-089-02
Clinical observation of Levofloxacin in treating 30 cases with mycoplasmal pneumonia
ZHANG Tiebiao
Department of Respiratory Medicine, the First Hospital of Huairou District, Beijing 101400, China
[Abstract] Objective: To investigate the effective treatment method of mycoplasmal pneumonia and to choose antibiotics reasonably. Methods: Clinical data of 52 cases with mycoplasmal pneumonia from January 2009 to December 2010 were collected and arranged, which were retrospectively analyzed. There were 22 cases in Azithromycin group, 30 cases in Levofloxacin group. The clinical curative effect of Azithromycin and Levofloxacin were analyzed. Results: The drug resistance of Azithromycin was increased, temperature of Azithromycin group was decreased slowly, and temperature of Levofloxacin group was decreased significantly, there was a statistically significant difference of the temperature between the two groups (P<0.05). The total effective rate of lung imaging absorption of Azithromycin group was 63.64%, which of Levofloxacin group was 100.00%, there was a statistically significant difference (χ2=15.432, P<0.01). Conclusion: Clinical effect of mycoplasmal pneumonia in the treatment with Levofloxacin is better than Azithromycin, it is worthy of promotion in clinic.
[Key words] Mycoplasmal pneumonia; Antibiotics; Levofloxacin; Azithromycin
有研究报道，支原体肺炎的发病率呈逐年上升趋势，支原体肺炎的治疗以往主要以大环内酯类抗生素为主，但由于大环内酯类抗生素的长期应用，使菌株对此类抗生素产生耐药性[1-5]。因此，寻求有效方法、合理应用抗生素治疗支原体肺炎是目前研究的重点。笔者通过观察采用大环内酯类抗生素阿奇霉素、喹诺酮类抗生素左氧氟沙星治疗支原体肺炎的疗效，旨在探讨支原体肺炎的有效治疗方法。现报道如下：
1 资料与方法
1.1 一般资料
收集整理2009年1月～2010年12月确诊为支原体肺炎患者52例的临床资料，按照治疗方法的不同分为两组，阿奇霉素组22例，其中，男9例，女13例，平均年龄(28.24±12.44)岁；左氧氟沙星组30例，其中，男12例，女18例，平均年龄(38.65±16.44)岁。两组患者在年龄、性别等方面比较，差异无统计学意义(P>0.05)，具有可比性。
1.2 方法
1.2.1 支原体检测方法 颗粒凝集实验 ......
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