胃肠外营养中氨基酸摄入量与极低出生体重儿胃肠外营养相关性胆汁淤积的关系分析(1)
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[摘要] 目的：探讨胃肠外营养(PN)中氨基酸摄入量与PN相关性胆汁淤积的关系，为减少和避免PN相关性胆汁淤积的发生提供依据。方法：对2005年12月～2008年5月低氨基酸组(采用PN方案)43例和2008年6月～2010年12月高氨基酸组(极低出生体重儿)39例的新生儿临床资料进行回顾性分析，比较两组PN相关性胆汁淤积发病率的差异。结果：低氨基酸组患儿氨基酸摄入量[(35.6±15.7)g/kg]小于高氨基酸组[(47.4±19.0)g/kg](P<0.01)；高氨基酸组患儿PN相关性胆汁淤积的发生率为41.0%，高于低氨基酸组[(18.6%)](P<0.05)。结论：在接受PN的极低出生体重儿中，摄入高剂量的氨基酸易发生PN相关性胆汁淤积，推荐采用低氨基酸PN方案。
[关键词] 极低出生体重儿；胃肠外营养；氨基酸；胃肠外营养相关性胆汁淤积
[中图分类号] R722 [文献标识码] A [文章编号] 1673-7210(2011)12(b)-038-03
Analysis of relationship between different amino acid intake on parenteral nutrition and the incidence of parenteral nutrition-associated cholestasis in very low birth weight infants
JIANG Xiaomei
Department of Neonatology, the People's Hospital of Laibin City, Guangxi Zhuang Autonomous Region, Laibin 546100, China
[Abstract] Objective: To analyze the relationship between different amino acid intake on parenteral nutrition (PN) and the incidence of parenteral nutrition-associated cholestasis in very low birth weight infants. Methods: 43 cases in low amino acid group hospitalized from December 2005 to May 2008 and 39 cases in high amino acid group hospitalized from June 2008 to December 2010, the data of the two groups were retrospectively analyzed and the incidence of PN associated cholestasis were compared. Results: Amino acids intake in children of low amino acid group [(35.6±15.7)g/kg] was less than that in children of high amino acid group [(47.4±19.0) g/kg], there was a significant difference between the two groups (P<0.01). The incidences of PN associated cholestasis in low amino acid group and high amino acid group were 18.6% and 41.0%, there was a significant difference between the two groups (P<0.05). Conclusion: The incidence of parenteral nutrition is associated with the higher amino acid intake, recommend the use of low amino of PN solutions.
[Key words] Very low birth weight infant; Parenteral nutrition; Amino acid; Parenteral nutrition-associated cholestasis
极低出生体重儿是指出生体重小于1 500 g的新生儿，绝大多数为早产儿。这些患儿常伴有严重疾病，且胃肠功能发育不完善，生后早期多表现为喂养不耐受 ......
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