甘精胰岛素和阿卡波糖联合治疗2型糖尿病疗效观察(1)
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[摘要] 目的：研究甘精胰岛素和阿卡波糖合用治疗2型糖尿病(T2DM)的疗效及该治疗方案对胰腺β细胞分泌功能的改善。方法：90例T2DM患者均给予甘精胰岛素和阿卡波糖治疗16周，检测治疗前及治疗16周后的空腹血糖值(FPG)、餐后2 h血糖值(2 h PG)、糖化血红蛋白(HbA1c)、空腹C肽(FCP)、餐后C肽(PCP)的变化。结果：经16周治疗后患者FPG、2 h PG、HbA1c分别下降为(6.91±1.50)mmol/L(t=1.669)、(8.28±2.12)mmol/L(t=2.136)、(6.51±1.03)%(t=1.663)，较治疗前明显下降，差异有统计学意义(P<0.05)；治疗后患者FCP、PCP分别上升为(3.42±0.42)μg/L(t=2.178)、(3.78±0.32)μg/L(t=2.752)，较治疗前明显上升，差异有统计学意义(P<0.05)。结论：甘精胰岛素和阿卡波糖合用治疗T2DM降糖效果好，并具有改善胰腺β细胞的内分泌功能的作用。
[关键词] 甘精胰岛素；阿卡波糖；2型糖尿病
[中图分类号] R587.2 [文献标识码] A [文章编号] 1673-7210(2012)01(a)-063-02
Therapeutic efficacy of Glargine Insulin combined with Acarbose in the treatment of patients with type 2 diabetes mellitus
ZHUANG Xiuyi, XIE Yingcai
Department of Pharmacy, the Affiliated Hospitial of Guangdong Medical College, Guangdong Province, Zhanjiang 524000, China
[Abstract] Objective: To study therapeutic efficacy of Glargine Insulin combined with Acarbose in the treatment of type 2 diabetes mellitus (T2DM) and the efficacy of secretory function of pancreatic β-cell protection and improvement. Methods: 90 patients with T2DM were given Glargine Insulin and Acarbose after 16 weeks of treatment. The change of fasting plasma glucose (FPG), postprandial 2 h blood glucose (2 h PG), glycosylated hemoglobin (HbA1c), fasting C peptide (FCP), postprandial C peptide (PCP) were detected after 16 weeks of treatment. Results: After 16 weeks of treatment in patients with FPG, 2 h PG, HbA1c decreased as the (6.91±1.50) mmol/L (t=1.669), (8.28±2.12) mmol/L (t=2.136), (6.51±1.03)% (t=1.663) descent, obviously after therapy, the differences were significant (P<0.05). FCP, PCP were increased to (3.42±0.42) μg/L (t=2.178), (3.78±0.32) μg/L (t=2.752), both were higher than before treatment, there were significant differences (P<0.05). Conclusion: The treatment of Glargine Insulin combined with Acarbose in T2DM has a good hypoglycemic effect and can improve the endocrine function of pancreatic β-cell ......
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