转铁蛋白和血红蛋白联合检测消化道出血的临床应用(1)
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[摘要] 目的 探讨血红蛋白法(OB)、转铁蛋白法(TF)和联合法检测消化道出血的临床应用价值。 方法 对1 944例临床标本分别使用转铁蛋白法、血红蛋白法和联合法进行潜血试验检测，并对结果进行比较分析。 结果 随机大便潜血试验阳性率转铁蛋白法为9.62%，血红蛋白法为5.76%，血红蛋白法与转铁蛋白法联合检测时为11.11%。其中，TF法、联合检测法与OB法阳性率比较，差异均有高度统计学意义(均 P < 0.01)，TF法与联合检测法比较，差异无统计学意义(P > 0.05)。 结论 转铁蛋白法是检测大便潜血试验敏感的方法，血红蛋白法的敏感度最低。应用转铁蛋白法可以提高大便潜血的阳性检出率，有利于消化道出血性疾病的诊断和鉴别诊断。
[关键词] 粪便潜血试验；免疫法；转铁蛋白；血红蛋白
[中图分类号] R57 [文献标识码] A [文章编号] 1673-7210(2012)01(b)-065-02
Clinical application of joint detection of transferrinsassay and hemoglobin in detecting fecal occult blood
LIN Liying1 ZHANG Yong2 YANG Subing3
1.Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical College, Guangdong Province, Guangzhou 510150, China; 2.Department of Clinical Laboratory Medicine, Guangzhou Hospital of TCM, Guangdong Province, Guangzhou 510130, China; 3. Department of Clinical Laboratory Medicine, Guangzhou Municipal Cancer Hospital, Guangdong Province, Guangzhou 510095, China
[Abstract] Objective To evaluate the clinical application of TF assay, OB assay and combination methods in the diagnosis of digestive hemorrhage. Methods 1 944 specimens were went on detection of fecal occult blood teats by TF assay, OB assay and combination method, the detected results of three methods were went on comparison and analysis. Results Among all the subjects, the positive rate of TF assay was 9.62%, the positive rate of OB assay was 5.76%, and the positive rate of combination methods was 11.11%. TF assay and combination methods compared with OB assay, the positive rate differences all had statistically significant (all P < 0.01), TF assay compared with the combination methods, the positive rate difference had no statistically significant (P > 0.05). Conclusion The TF assay is a sensitivite method to detect the digestive hemorrhage.Using of TF assay is helpful to diagnosis the disease of digestive hemorrhage
[Key words] Fecal occult blood teats；Immunoassay；Transferrinsassay；Hemoglobin
便隐血试验(OBT)是指消化道出血量少，肉眼不见血色，而且少量红细胞又被消化分解，以至显微镜下也无从发现的出血[1-3]。正常人粪便隐血试验为阴性。其阳性常见于消化性溃疡的活动期、胃癌、钩虫病以及消化道炎症、出血性疾病等；消化性溃疡呈间断阳性 ......
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