抗缪勒管激素和血清抑制素B检测对卵巢储备功能预测的价值(1)
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[摘要] 目的 探讨血清抑制素B(INHB)及抗缪勒管激素(AMH)的检测对卵巢储备功能预测的临床价值。 方法 采用酶联免疫吸附法(ELISA)及化学发光法对108例不孕症患者(卵巢低反应组37例、卵巢正常反应组71例)于月经第3天检测血清AMH、INHB及卵泡刺激素(FSH)水平，并采用彩色超声检查方式测量窦卵泡计数(AFC)。 结果 卵巢低反应组FSH水平[(9.89±1.01)mIU/mL]明显高于卵巢正常反应组[(6.68±0.96)mIU/mL]，卵巢低反应组AMH水平[(0.39±0.09)ng/L]、INHB水平[(68.43±10.16)ng/L]及AFC[(5.98±0.96)个]明显低于卵巢正常反应组[(1.51±0.57) ng/L、(128.68±17.42)ng/L、(11.52±2.31)个]，差异均有统计学意义(均P < 0.05)；卵巢低反应患者AFC与血清AMH、INHB水平呈正相关(r = 0.62、0.43，均P < 0.05)；AMH(ROCAUC=0.897，P < 0.05)及INHB(ROCAUC=0.886，P < 0.05)对卵巢储备功能的预测能力较强。 结论 血清中AMH及INHB水平检测对卵巢储备功能的预测具有较高的临床价值。
[关键词] 抗缪勒管激素；血清抑制素B；卵巢储备
[中图分类号] R711 [文献标识码] A [文章编号] 1673-7210(2012)01(b)-106-02
Clinical significance of detecting serum levels of AMH and INHB in predicting the ovarian reserve
LIANG Xiuyun1 MO Fengmei2
1.Department of Clinical Laboratory, the Second People′s Hospital of Nanning City, Guangxi Zhuang Autonomous Region, Nanning 530031, China; 2.Department of Gynecology, Reproductive Center of Nanning City, Guangxi Zhuang Autonomous Region, Nanning 530031, China
[Abstract] Objective To explore the clinical significance in predicting the ovarian reserve by detecting serum levels of AMH and INHB. Methods On the third day of a spontaneous cycle, the serum levels of AMH, INHB, FSH were detected with enzyme linked immunosorbent assays (ELISA) and immunoenzymatic assay in 108 patients (37 patients with poor ovarian response, 71 patients with normal ovarian response), at the same day, AFC was determined by transvaginal color Doppler. Results The serum level of FSH [(9.89±1.01)mIU/mL] in the poor ovarian response group was significantly higher than that [(6.68±0.96)mIU/mL] in the normal ovarian response group (P < 0.05). The serum levels of AMH [(0.39±0.09)ng/L], INHB [(68.43±10.16)ng/L], AFC (5.98±0.96) in the poor ovarian response group were significantly lower than those [(1.51±0.57)ng/L, (128.68±17.42)ng/L, (11.52±2.31)] in the normal ovarian response group (all P < 0.05). The serum levels of AMH and INHB were positively correlated with AFC (r = 0.62, 0.43, all P < 0.05) in the poor ovarian response group ......
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