格林-巴利综合征患者血清肿瘤坏死因子α及髓鞘碱性蛋白水平变化(1)
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[摘要] 目的 探讨格林-巴利综合征患者血清肿瘤坏死因子α(TNF-α)及血清髓鞘碱性蛋白(MBP)的变化情况及两者在格林-巴利综合征发病中的作用。 方法 选择我院2005~2010年收治的格林-巴利综合征患者30例，作为研究组，选择同期健康体检者30例作为对照组，分别检测各组患者血TNF-α及MBP变化情况，并进行组间及组内比较。 结果 研究组患者血清TNF-α及MBP水平均高于对照组，差异均有统计学意义(P < 0.05)；在格林-巴利综合征患者中，血TNF-α及MBP水平随病情的加重而升高，且不同病情分级患者上述指标差异有统计学意义(P < 0.05)。 结论 血清肿瘤坏死因子-α及髓鞘碱性蛋白与格林-巴利综合征患者发病及病情轻重有重要关系，临床密切监测该指标有助于格林-巴利综合征的发现及病情判断。
[关键词] 格林-巴利综合征；肿瘤坏死因子α；髓鞘碱性蛋白
[中图分类号] R745.4 [文献标识码] A [文章编号] 1673-7210(2012)01(c)-0046-02
The change of serum tumor necrosis factor-α and myelin basic protein levels in patients with Guillain-Barre syndrome
WANG Yueying
The First Department of Cardiology and Neurology, the People's Hospital of Guantao County, Hebei Province, Guantao 057750, China
[Abstract] Objective To explore the change of serum tumor necrosis factor-α (TNF-α) and myelin basic protein (MBP) of patients with Guillain-Barre syndrome and discuss the roles of TNF-α and MBP in the morbidity of Guillain-Barre syndrome. Methods 30 cases of patients who were diagnosed with Guillain-Barre syndrome were selected as study group in our hospital from 2005 to 2010, while 30 cases of healthy people were selected as control group during the same period. Serum TNF-α and MBP levels of the two groups were detected and compared in group and between groups respectively. Results Serum TNF-α and MBP levels of study group were higher than that of control group, the differences were statistically significance (P < 0.05). The illness state was worse with the increase of serum TNF-α and MBP levels in patients with Guillain-Barre syndrome, and there were statistically significant differences among patients with different classes of illness state (P < 0.05). Conclusion There is an important relationship between the incidence and severity of Guillain-Barre syndrome and serum TNF-α and MBP level. Closely monitoring the two indicators can help us to identify and determine the illness state of Guillain-Barre syndrome.
[Key words] Guillain-Barre syndrome; Tumor necrosis factor α; Myelin basic protein ......
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