盐酸戊乙奎醚注射液与硫酸阿托品用于老年患者术前用药的疗效比较(1)
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[摘要] 目的 比较盐酸戊乙奎醚注射液(长托宁)与硫酸阿托品用于老年患者术前用药的疗效。 方法 选择我院收治的择期手术的老年患者60例，将其随机分为观察组和对照组，各30例。对照组术前使用硫酸阿托品，观察组术前使用长托宁。 结果 观察组注药15、30 min后心率明显高于治疗前，差异有统计学意义(P < 0.05)。对照组注药后心率、收缩压、血氧饱和度与注药前相比，差异无统计学意义(P > 0.05)。 结论 长托宁用于老年患者术前用药，可以减少对患者心率和血压的影响，是一种理想的老年患者全身麻醉前用药。
[关键词] 长托宁注射液；硫酸阿托品；术前用药
[中图分类号] R614 [文献标识码] A [文章编号] 1673-7210(2012)01(c)-0083-02
Therapeutic efficacy comparison of Penehyclidine Hydrochloride Injection and Atropine Sulfate on premedication of elderly patients
AN Yuanchun WEI Yingjiao
Department of Anesthesiology, Xingtan Hospital of Shunde District in Foshan City, Guangdong Province, Foshan 528325, China
[Abstract] Objective To compare the therapeutic efficacy of Penehyclidine Hydrochloride Injection and Atropine Sulfate on premedication of elderly patients. Methods 60 elderly patients undergoing selective operation in our hospital were selected and randomly divided into observation group and control group. Patients in the control group were given Atropine Sulfate before operation, and patients in the observation group were given Penehyclidine Hydrochloride Injection before operation. Results In the observation group, the heart rate at 15 min and 30 min after injection was significantly higher than before injection, the difference was significant (P < 0.05). In the control group, there were no significant differences of the heart rate, systolic blood pressure and oxygen saturation before and after injection (P > 0.05). Conclusion The premedication of Penehyclidine Hydrochloride Injection for elderly patients can reduce the impact on heart rate and blood pressure, thus is an ideal medication before general anesthesia in elderly patients.
[Key words] Penehyclidine Hydrochloride Injection; Atropine sulfate; Premedication
老年患者术前多合并心脑血管、呼吸系统疾病，选择合理的术前用药，减轻患者因麻醉及手术操作刺激引起的应激反应和有效对抗全麻药的副作用具有积极意义。本课题中，笔者比较了盐酸戊乙奎醚注射液(商品名：长托宁)及硫酸阿托品用于老年患者术前用药的效果，现报道如下：
1 资料与方法
1.1 一般资料
选取2010年1月～2011年8月在我院收治的择期手术的老年患者60例作为研究对象，其中，男35例，女25例；年龄60～78岁；所有患者均无手术禁忌证。按就诊顺序将其随机分为观察组和对照组。观察组30例，其中，男17例，女13例；平均年龄(67.5±3.4)岁。对照组30例，其中，男18例，女12例；平均年龄(67.3±3.8)岁。两组择期手术的老年患者性别比、年龄等一般资料比较差异无统计学意义(P > 0 ......
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