血浆同型半胱氨酸水平与血管性痴呆的相关性研究(1)
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[摘要] 目的 探讨血浆同型半胱氨酸(HCY)水平与血管性痴呆(VD)的相关性。 方法 按诊断标准将我院脑梗死住院患者分别纳入VD组(78例)和非痴呆组(202例)，另选取同期同龄正常体检者100例为对照组。检测并比较三组间的HCY浓度，并借助简易精神状态速检表(MMSE)对VD组进行痴呆程度分类，分析其与HCY之间的关系。 结果 VD组和非痴呆组的HCY浓度均高于对照组，且以VD组最高(P < 0.05)；随着痴呆程度的加重，MMSE评分逐渐降低，HCY的浓度则逐渐升高，MMSE评分和HCY浓度二者之间呈负相关(r = -0.703，P<0.05)。 结论 深化HCY与VD关系的认识，监测HCY浓度，有利于VD的防治。
[关键词] 血浆同型半胱氨酸；血管性痴呆；相关性
[中图分类号] R743 [文献标识码] A [文章编号] 1673-7210(2012)02(a)-0040-02
Study on the correlation between plasma homocysteine levels and vascular dementia
LU Shaohuan
Department of Internal Medicine, the Fifth People's Hospital of Foshan City, Guangdong Province, Foshan 528211, China
[Abstract] Objective To study the correlation between plasma homocysteine (HCY) levels and vascular dementia (VD). Methods According to cliagnostic criteria, 78 cases of VD patients (VD group), 202 cases of patients with non-demented cerebral infarction (non-demented group) and 100 normal healthy persons (control group) in our hospital were recruited in the study. Their total plasma HCY levels were measured with enzymatic cycle detection. The severity of cognition impairment in VD patients was classified by mini-mental state examination (MMSE) scores. The relationship between MMSE′s scores with HCY concentrations was analyzed. Results The mean of plasma HCY concentrations in the VD group and non-demented group were higher than that in the control group, and was highest in the VD group (P < 0.05). MMSE scores was decreased and plasma HCY concentrations were increased with the severity of dementia, and there were negative correlation (r = -0.703, P < 0.05) between MMSE scores and plasma HCY concentrations. Conclusion To deepen the relationship of HCY and VD, and monitor HCY concentration, which are conducive to prevention and treatment of VD.
[Key words] Plasma homocysteine; Vascular dementia; Correlation
血管性痴呆(VD)是我国老年人的常见病和多发病，也是继阿尔茨海默病(AD)之后位列第2位最常见的痴呆，占所有痴呆疾病的10%~50%[1]。到目前为止，VD的发病机制仍未完全阐明，但已有研究提示血浆同型半胱氨酸(HCY)可能是VD发生的一个独立危险因素，所以笔者围绕HCY水平与血管性痴呆的相关性展开进一步探讨 ......
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