急性冠脉综合征患者超敏C反应蛋白变化及与冠脉病变程度的关系(1)
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[摘要] 目的 探讨超敏C反应蛋白(hs-CRP)在急性冠脉综合征(ACS)患者中的差别，并探讨其与ACS患者冠脉病变严重程度的关系及其临床意义。 方法 序贯入选住院并接受冠脉造影ACS患者共105例，按临床诊断将ACS患者分为三组，再根据Gensini积分将其再分为三组进行比较分析。另设稳定性心绞痛(SA)组和正常冠脉组，将其作为对照组。入院即刻抽取患者静脉血进行hs-CRP检查。结果 ①ACS患者(包括不同临床类型亚组)的hs-CRP水平均高于SA组和正常冠脉组，差异具有统计学意义(P < 0.05)。②hs-CRP水平在不同冠脉病变程度ACS患者中存在差异(P < 0.05)且hs-CRP水平与反映冠脉病变程度的Gensini积分存在正相关(r = 0.741，P < 0.05 )。 结论 ACS患者的hs-CRP水平显著高于SA组及正常冠脉组水平，且与冠脉病变的严重程度有关，hs-CRP可作为临床上评价入院ACS患者危险程度的简单、有效、实用的方法。
[关键词] 急性冠脉综合征；超敏C反应蛋白；Gensini积分
[中图分类号] R743.32 [文献标识码] A [文章编号] 1673-7210(2012)02(a)-0056-03
Study on the levels of hs-CRP in ACS patients and its relationships with the extent of the coronary artery lesion
KOU Jinghua1 CUI Xiupeng2 WEI Peng3
1.Department of Radiology, the First People's Hospital of Dongping County, Shangdong Province, Dongping 221009, China; 2.College of Clinical Medical, Jiangsu University, Jiangsu Province, Zhenjiang 212013, China; 3.Department of Cardiology, the Central Hospital of Xuzhou City, Jiangsu Province, Xuzhou 221009, China
[Abstract] Objective To study the diversity of levels of high-sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS), and to investigate the relationships between the biochemical markers and the extent of coronary artery lesions of ACS, and to assess the clinical value. Methods A total of 105 cases of ACS admitted were divided into three clinical types. These patients were also evaluated by Gensini score for a decision of coronary angiography (CAG) after admission, and divided into three groups. Stable angina patients and normal volunteers were designated as control group. The venous blood samples were taken from the patients immediately after admission for detection of hs-CRP. Results ①Significant differences in hs-CRP were found between ACS group including the different clinical subgroups and SA group/ normal group (P < 0.05). ②Significant differences in hs-CRP were found among three ACS groups which were divided according to the severity of coronary artery disease in patients (P < 0 ......
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