前列地尔脂微球载体制剂对慢性充血性心力衰竭的疗效观察(1)
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[摘要] 目的 观察在常规慢性充血性心力衰竭治疗基础上加用前列地尔脂微球载体制剂对患者心功能的改善情况。 方法 将40例慢性充血性心力衰竭患者随机分为治疗组(20例)和对照组(20例)，对照组采用常规心力衰竭药物治疗，治疗组在此基础上加用前列地尔脂微球载体制剂10 μg，每日1次，连续应用10 d。比较两组治疗前后血浆B型脑钠肽(BNP)水平、超声心动图(左室射血分数、左室短轴缩短率、搏出量、左室舒张末期内径)及6 min步行距离的变化。 结果 治疗组较对照组左室射血分数、搏出量及左室短轴缩短率增加(P < 0.05)，左室舒张末期内径减小(P < 0.05)，血浆BNP水平显著下降(P < 0.05)，6 min步行距离明显延长。 结论 前列地尔脂微球载体制剂可进一步提高慢性充血性心力衰竭患者心功能。
[关键词] 前列地尔；慢性充血性心力衰竭；B型脑钠肽；6 min步行距离；超声心动
[中图分类号] R541.61 [文献标识码] A [文章编号] 1673-7210(2012)02(a)-0075-02
Observation of curative effect on Alprostadil Lipo-preparation in the treatment of chronic congestive heart failure
LIU Dongxia LI Shuren WU Huizhen WU Di
The First Department of Cardiology, the People's Hospital of Hebei Province, Shi Jiazhuang 050051, China
[Abstract] Objective To investigate the improvement of Alprostadil Lipo-preparation to the cardiac function based on conventional treatment of chronic congestive heart failure. Methods 40 cases with chronic congestive heart failure were randomly divided into treatment group (20 cases) and control group (20 cases). The control group was given conventional treatment of heart failure, on basis of which, the treatment group was given additional Alprostadil Lipo-preparation 10 μg intravenously for 10 days. The differences of plasma brain natriuretic peptide (BNP) level, echocardiography (left ventricular ejection fraction, left ventricular fractional shortening, stroke volume, left ventricular end diastolic diameter) and 6-minute walking distance before and after treatment between the two groups were compared. Results Compared with control group, in the treatment group, the left ventricular ejection fraction, left ventricular fractional were shorten (P < 0.05), stroke volume was significantly improved and left ventricular end diastolic diameter was significantly reduced (P < 0.05), plasma BNP level was reduced and 6-minute walking distance was prolonged significantly (P < 0.05). Conclusion Alprostadil Lipo-preparation can further improve cardiac function of patients with chronic congestive heart failure.
[Key words] Alprostadil; Chronic congestive heart failure; Brain natriuretic peptide; 6 minute walking distance; Echocardiography ......
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