MMP-9、hs-CRP、BNP、S-100和DD对急性缺血性脑卒中患者预后的影响(1)
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[摘要] 目的 观察MMP-9、hs-CRP、BNP、S-100和DD对急性缺血性脑卒中(AIS)患者预后的影响。 方法 选取确诊为AIS的患者53例，检测MMP-9、hs-CRP、BNP、S-100和DD水平并进行随访，采用SAS 9.1.3统计学软件包Kaplan-Meier法进行生存分析，采用Cox回归进行单因素分析和Cox逐步回归进行多因素分析，研究各指标对AIS预后的影响。 结果 单因素Cox回归分析显示，年龄和性别对AIS预后无影响(P > 0.05)；多因素Cox逐步回归分析结果显示，MMP-9、hs-CRP、BNP、S-100和DD是AIS预后的危险因素(P < 0.05)，尤其是S-100对AIS预后影响最大。 结论 MMP-9、hs-CRP、BNP、S-100和DD与AIS预后密切相关，尤其以S-100影响最为显著。
[关键词] 急性缺血性脑卒中；生物标志物；生存率；预后
[中图分类号] R743.3 [文献标识码] A [文章编号] 1673-7210(2012)08(b)-0022-02
Influence of MMP-9, hs-CRP, BNP, S-100 and DD on the prognosis of patients with acute ischemic stroke
LIANG Heng HAN Jiangquan LI Jizhong LIN Dongrong YANG Zhenying
The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical College, Guangdong Province, Zhuhai 519100, China
[Abstract] Objective To observe the influence of MMP-9, hs-CRP, BNP, S-100 and DD on the prognosis of patients with acute ischemic stroke. Methods 53 cases of patients who were diagnosed with AIS were selected. MMP9, hs-CRP, BNP, S -100 and DD levels of patients were detected and all of them were followed up. SAS 9.1.3 software and Kaplan-Meier method were adopted to analyze the survival rate; Cox regression was adopted to carry out univariate analysis and Cox stepwise regression was adopted to carry out multivariate analysis. Then the influence of various indexes in the study on the prognosis of AIS was researched. Results Univariate Cox regression analysis showed that age and gender had no effect on the prognosis of AIS (P < 0.05); multivariate Cox stepwise regression analysis results showed that MMP-9, hs-CRP, BNP, S-100 and DD were the risk factors for the prognosis of AIS (P < 0 ......
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