心肌酶谱在类风湿性关节炎患者血清中的变化及临床意义(2)
![]() |
第1页 |
参见附件。
本研究结果显示活动组的血清AST、LDH、CK、CK-MB显著高于非活动组(P < 0.05),非活动组的血清AST、LDH、CK、CK-MB显著高于对照组(P < 0.05),由此可见活动性RA的心肌损伤程度比非活动性RA患者更为严重,这与Turiel等[8]报道一致。但是活动组患者血清AST、LDH、CK、CK-MB在治疗后均显著下降(P < 0.05),这说明RA心肌损伤在一定程度上是可控的,通过干预措施可以取得较好的疗效,因此在RA患者诊治过程中,我们应定期监测其心肌酶谱,做到早期发现、早期治疗,严防心脏不良事件的发生。
[参考文献]
[1] Myasoedova E,Crowson CS,Nicola PJ,et al. The influence of rheumatoid arthritis disease characteristics on heart failure [J]. J Rheumatol,2011,38(8):1601-1606.
[2] Aggarwal R,Liao K,Nair R,et al. Anti-citrullinated peptide antibody assays and their role in the diagnosis of rheumatoid arthritis [J]. Arthritis Rheum,2009,61(11):1472-1483.
[3] Tutunov VS,Popkova TV,Novikova DS,et al. Comparative assessment of anti inflammatory action of atorvastatin in ischemic heart disease and rheumatoid arthritis [J]. Kardiologiia,2008,48(9):4-8.
[4] Davis JM,Roger VL,Crowson CS,et al. The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population [J]. Arthritis Rheum,2008,58(9):2603-2611.
[5] Goulenok TM,Meune C,Gossec L,et al. Usefulness of routine electrocardiography for heart disease screening in patients with spondyloarthropathy or rheumatoid arthritis [J]. Joint Bone Spine,2010,77(2):146-150.
[6] Balion CM,Santaguida P,McKelvie R,et al. Physiological,pathological,pharmacological,biochemical and hematological factors affecting BNP and NT-proBNP [J]. Clin Biochem,2008,41(4-5):231-239.
[7] Wang FW,Zhao JG,Wang Y,et al. The dynamic change of serum CK,CK-MB and myocardium histomorphology after exhausted exercise in rats [J]. Zhongguo Ying Yong Sheng Li Xue Za Zhi,2011,27(1):52-55.
[8] Turiel M,Sitia S,Atzeni F,et al. The heart in rheumatoid arthritis [J]. Autoimmun Rev,2010,9(6):414-418.
(收稿日期:2012-09-21 本文编辑:郝明明)
您现在查看是摘要介绍页,详见PDF附件(2099kb)。