[摘要] 心血管病是慢性肾脏病(CKD)患者最常见的并发症，心脏瓣膜钙化(CVC)是CKD患者心血管事件的重要危险因素之一。CVC不仅能导致瓣膜狭窄和/或关闭不全，还可引起心肌缺血或梗死、心律失常，甚至心源性猝死。高血压、高脂血症、高血糖、高血磷与钙磷乘积、甲状旁腺激素、炎症与氧化应激等是CKD患者CVC的危险因素。与其相关的分子机制，如内皮间质转化、Wnt-β catenin通路、胎球蛋白A、核因子-κB等，也参与了促进或抑制CVC的过程。

    [关键词] 慢性肾脏病；瓣膜钙化；内皮间质转化

    [中图分类号] R692 [文献标识码] A [文章编号] 1673-7210(2016)01(b)-0033-04

    [Abstract] Cardiovascular disease is the most common complication in chronic kidney disease (CKD). Cardiac valve calcification (CVC) is one of the most important causes to increase the risk of cardiovascular events in terms of CKD patients. CVC can cause not only valve stenosis and/or incompetence but also myocardial infarction ......