验方颗粒剂治疗湿热蕴结型痛风性关节炎临床观察(1)
[摘要] 目的 观察验方颗粒剂治疗湿热蕴结型痛风性关节炎的临床效果。 方法 选择2015年6～12月西安市中医医院痛风性关节炎患者50例，采用随机数字表法分为对照组和治疗组，每组各25例。对照组口服秋水仙碱片和美洛昔康片，治疗组口服验方颗粒剂，用药2个疗程后比较两组患者中医证候积分、实验室指标、不良反应发生率及总有效率。 结果 治疗组总有效率(96.0%)明显优于对照组(76.0%)(P < 0.05)。治疗后，对照组与治疗组血沉(ESR)[(38.72±15.60)、(34.72±18.40)mm/h]、超敏C反应蛋白(hs-CRP)[(12.79±8.68)、(10.66±10.22)mg/L]与治疗前[(67.44±15.80)、(70.25±14.21)mm/h；(29.60±7.49)、(27.08±9.91)mg/L]比较，差异有高度统计学意义(P < 0.01)；治疗后两组ESR和hs-CRP比较，差异无统计学意义(P > 0.05)。治疗后，对照组与治疗组中医证候积分[(13.2±9.97)比(4.97±5.20)分]、血尿酸 [(681.80±94.93)比(618.64±103.98)μmol/L]、三酰甘油[(4.36±1.03)比(3.52±1.43)mmol/L]、总胆固醇[(7.48±1.09)比(6.88±0.89)mmol/L]比较，差异均有统计学意义(P < 0.05)。两组不良反应发生率比较，差异有统计学意义(P < 0.05)。 结论 验方颗粒剂治疗湿热蕴结型痛风能明显缓解症状、降低血尿酸和血脂水平，预防痛风复发，疗效确切，值得推广。
[关键词] 验方颗粒剂；痛风性关节炎；湿热蕴结型
[中图分类号] R259 [文献标识码] A [文章编号] 1673-7210(2016)06(a)-0086-04
[Abstract] Objective To observe the clinical effect of empirical-formulae granule on treating gouty arthritis of dampness-heat accumulation type. Methods From June to December 2015， in Xi'an Municipal TCM Hospital， 50 gout dampness-heat accumulation type patients were selected， and they were devided into the control group (25 cases) and the treated group (25 cases) according to random number table. The control group was given Colchicine Tablets 986 and Meloxicam Tablets， while the treated group was given empirical-formulae granule. Then the traditional Chinese medicine syndrome scores， the laboratory indexes， the adverse reaction rate， and the total effective rate were compared after two courses of treatment. Results The total effective rate in the treated group (96.0%) was better than that of control group (76.0%) (P < 0.05). After treatment， the ESR [(38.72±15.60)， (34.72±18.40) mm/h] and hs-CRP [(12.79±8.68)， (10.66±10.22) mg/L] in control group and treated group were lower than those before treatment [(67.44±15.80)， (70.25±14.21) mm/h； (29.60±7.49)， (27.08±9.91 )mg/L]， the differences were statistically significant (P < 0.01)； but these in two group after treatment were compared， the differences were not statistically significant (P > 0.01). After treatment， the symtom scores [(13.2±9.97) vs (4.97±5.20) scores]， UA [(681.80±94.93) vs (618.64±103.98) μmol/L]， TG [(4.36±1.03) vs (3.52±1.43) mmol/L]， TC [(7.48±1.09) vs (6.88±0.89) mmol/L] in control group were compared with treatment group， the differences were statistically significant (P < 0.01). Conclusion Empirical-formulae granule used in the treatment of gouty arthritis of dampness-heat accumulation type can significantly alleviate clinical symptoms， reduce the levels of UA， TG， TC， and prevent gout's recurrence. It has advantage in curative effect， deserve the clinical expansion. (安琦 白小林 裴瑞霞)
[关键词] 验方颗粒剂；痛风性关节炎；湿热蕴结型
[中图分类号] R259 [文献标识码] A [文章编号] 1673-7210(2016)06(a)-0086-04
[Abstract] Objective To observe the clinical effect of empirical-formulae granule on treating gouty arthritis of dampness-heat accumulation type. Methods From June to December 2015， in Xi'an Municipal TCM Hospital， 50 gout dampness-heat accumulation type patients were selected， and they were devided into the control group (25 cases) and the treated group (25 cases) according to random number table. The control group was given Colchicine Tablets 986 and Meloxicam Tablets， while the treated group was given empirical-formulae granule. Then the traditional Chinese medicine syndrome scores， the laboratory indexes， the adverse reaction rate， and the total effective rate were compared after two courses of treatment. Results The total effective rate in the treated group (96.0%) was better than that of control group (76.0%) (P < 0.05). After treatment， the ESR [(38.72±15.60)， (34.72±18.40) mm/h] and hs-CRP [(12.79±8.68)， (10.66±10.22) mg/L] in control group and treated group were lower than those before treatment [(67.44±15.80)， (70.25±14.21) mm/h； (29.60±7.49)， (27.08±9.91 )mg/L]， the differences were statistically significant (P < 0.01)； but these in two group after treatment were compared， the differences were not statistically significant (P > 0.01). After treatment， the symtom scores [(13.2±9.97) vs (4.97±5.20) scores]， UA [(681.80±94.93) vs (618.64±103.98) μmol/L]， TG [(4.36±1.03) vs (3.52±1.43) mmol/L]， TC [(7.48±1.09) vs (6.88±0.89) mmol/L] in control group were compared with treatment group， the differences were statistically significant (P < 0.01). Conclusion Empirical-formulae granule used in the treatment of gouty arthritis of dampness-heat accumulation type can significantly alleviate clinical symptoms， reduce the levels of UA， TG， TC， and prevent gout's recurrence. It has advantage in curative effect， deserve the clinical expansion. (安琦 白小林 裴瑞霞)