缺血性脑卒中患者Lp—PLA2水平及意义(1)
[摘要] 目的 探讨缺血性脑卒中患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)的水平及意义，同时分析Lp-PLA2与胆固醇(CHO)、低密度脂蛋白(LDL)、三酰甘油(TG)的相关性。 方法 选择2015年1月～2016年1月于沧州市人民医院神经内科确诊缺血性脑卒中住院治疗的200例患者作为试验组，另选择同时期200名健康体检者作为对照组，分别检测两组研究对象Lp-PLA2、CHO、LDL、TG的血清水平。收集所得数据并进行整理后，使用统计软件SPSS 17.0对数据进行统计学分析，采用Pearson检验分析其相关性。 结果 试验组患者血清Lp-PLA2、CHO、LDL、TG水平明显高于对照组，差异有统计学意义(P < 0.05)，缺血性脑卒中患者血清中Lp-PLA2水平与TG、CHO、LDL均呈正相关(r=0.689、0.755、0.889，P < 0.05)。 结论 血清Lp-PLA2水平在缺血性脑卒中患者中明显增高，与CHO、LDL、TG具有相关性，是缺血性脑卒中的危险因素之一。
[关键词] 缺血性脑卒中；脂蛋白相关磷脂酶A2；胆固醇；低密度脂蛋白；三酰甘油
[中图分类号] R74 [文献标识码] A [文章编号] 1673-7210(2017)06(b)-0050-04
Lp-PLA2 level and its significance in patients with ischemic stroke
HAN Xiaoxia ZUO Ruiju HAN Tingting MA Xiao
Department of Clinical Laboratory， Cangzhou People′s Hospital， Hebei Province， Cangzhou 061000， China
[Abstract] Objective To investigate the level and significance of serum lipoprotein associated phospholipase A2 (Lp-PLA2) in patients with ischemic stroke， in order to analyze the correlation between Lp-PLA2 and cholesterol (CHO)， low density lipoprotein (LDL) and triglyceride (TG). Methods From January 2015 to January 2016， 200 patients with ischemic stroke diagnosed and treated at Department of Neurology， Cangzhou People′s Hospital neurology department were selected as the experimental group， and 200 healthy cases were selected as control group， The serum levels of Lp-PLA2， CHO， LDL and TG in the two groups were detected. The collected data were analyzed by statistical software SPSS 17.0. The correlation was analyzed by Pearson test. Results The serum levels of Lp-PLA2， CHO， LDL and TG in the experimental group were higher than those in the control group， with statistically significant difference (P < 0.05). The levels of Lp-PLA2 in patients with ischemic stroke were positively correlated with the levels TG， CHO， and LDL (r=0.689， 0.755， 0.889， P < 0.05). Conclusion The level of Lp - PLA2 in patients with ischemic stroke is increased， and it is correlated with the levels of TG， CHO， and LDL， which is one of the risk factors for ischemic stroke.
[Key words] Ischemic stroke； Lipoprotein associated phospholipase A2； Cholesterol； Low density lipoprotein； Triglyceride
随着人们生活质量的不断提高，心脑血管疾病的发病率也在逐年上升；其中缺血性脑卒中不仅发病率高，而且该病致残率、致死率、复发率也极高，这给家庭和社会带来了沉重负担，因此早期监测、早期干预，加强缺血性脑卒中发病的预防工作尤为重要。已知动脉硬化是引起缺血性脑卒中的最主要原因。脂蛋白相关磷脂酶A2(Lp-PLA2)又称血小板活化因子乙酰水解酶(PAF-AH)，在血管发生病变时，由动脉粥样斑块中的巨噬细胞和其他炎症细胞合成受炎症介质调节的酶，具有高度特异性，极低变异性[1-2]。近些年有研究人员发现，Lp-PLA2可作为动脉粥样性病变发生的炎症标志物。作為动态指标，测定Lp-PLA2可以反映炎性反应过程；同时作为新近发展的一项检测项目，其检测无需复杂设备、可操作性强，较之于影像学方法更加便于开展。另外胆固醇(CHO)、低密度脂蛋白胆固醇(LDL)、三酰甘油(TG)作为血脂检查的常规项目，被证实为缺血性脑卒中的危险因素[3]。为此本研究旨在探讨血清中Lp-PLA2与缺血性脑卒中的关系，同时就缺血性脑卒中其他影响因素CHO、LDL、TG进行探讨分析。, http://www.100md.com(韩晓霞 左瑞菊 韩婷婷 马肖)
[关键词] 缺血性脑卒中；脂蛋白相关磷脂酶A2；胆固醇；低密度脂蛋白；三酰甘油
[中图分类号] R74 [文献标识码] A [文章编号] 1673-7210(2017)06(b)-0050-04
Lp-PLA2 level and its significance in patients with ischemic stroke
HAN Xiaoxia ZUO Ruiju HAN Tingting MA Xiao
Department of Clinical Laboratory， Cangzhou People′s Hospital， Hebei Province， Cangzhou 061000， China
[Abstract] Objective To investigate the level and significance of serum lipoprotein associated phospholipase A2 (Lp-PLA2) in patients with ischemic stroke， in order to analyze the correlation between Lp-PLA2 and cholesterol (CHO)， low density lipoprotein (LDL) and triglyceride (TG). Methods From January 2015 to January 2016， 200 patients with ischemic stroke diagnosed and treated at Department of Neurology， Cangzhou People′s Hospital neurology department were selected as the experimental group， and 200 healthy cases were selected as control group， The serum levels of Lp-PLA2， CHO， LDL and TG in the two groups were detected. The collected data were analyzed by statistical software SPSS 17.0. The correlation was analyzed by Pearson test. Results The serum levels of Lp-PLA2， CHO， LDL and TG in the experimental group were higher than those in the control group， with statistically significant difference (P < 0.05). The levels of Lp-PLA2 in patients with ischemic stroke were positively correlated with the levels TG， CHO， and LDL (r=0.689， 0.755， 0.889， P < 0.05). Conclusion The level of Lp - PLA2 in patients with ischemic stroke is increased， and it is correlated with the levels of TG， CHO， and LDL， which is one of the risk factors for ischemic stroke.
[Key words] Ischemic stroke； Lipoprotein associated phospholipase A2； Cholesterol； Low density lipoprotein； Triglyceride
随着人们生活质量的不断提高，心脑血管疾病的发病率也在逐年上升；其中缺血性脑卒中不仅发病率高，而且该病致残率、致死率、复发率也极高，这给家庭和社会带来了沉重负担，因此早期监测、早期干预，加强缺血性脑卒中发病的预防工作尤为重要。已知动脉硬化是引起缺血性脑卒中的最主要原因。脂蛋白相关磷脂酶A2(Lp-PLA2)又称血小板活化因子乙酰水解酶(PAF-AH)，在血管发生病变时，由动脉粥样斑块中的巨噬细胞和其他炎症细胞合成受炎症介质调节的酶，具有高度特异性，极低变异性[1-2]。近些年有研究人员发现，Lp-PLA2可作为动脉粥样性病变发生的炎症标志物。作為动态指标，测定Lp-PLA2可以反映炎性反应过程；同时作为新近发展的一项检测项目，其检测无需复杂设备、可操作性强，较之于影像学方法更加便于开展。另外胆固醇(CHO)、低密度脂蛋白胆固醇(LDL)、三酰甘油(TG)作为血脂检查的常规项目，被证实为缺血性脑卒中的危险因素[3]。为此本研究旨在探讨血清中Lp-PLA2与缺血性脑卒中的关系，同时就缺血性脑卒中其他影响因素CHO、LDL、TG进行探讨分析。, http://www.100md.com(韩晓霞 左瑞菊 韩婷婷 马肖)