血脂水平异常与结直肠癌肝转移的相关性研究(1)
[摘要] 目的 探讨血脂水平异常与结直肠癌肝转移的关系 。方法 回顾性分析2008年6月～2016年3月宝鸡市中医医院普外科及肛肠科收治的336例结直肠癌患者的临床资料，分析比较结直肠癌肝转移组(52例)及非肝转移组(284例)患者的一般临床资料及初次血脂水平，分析结直肠癌肝转移与血脂水平及异常血脂类型之间的关系。 结果 结直肠癌肝转移组的肿瘤浸润深度、是否有区域淋巴结转移及肿瘤分化程度与无肝转移组差异有统计学意义(P < 0.05)，两组初次CEA水平差异无统计学意义(P > 0.05)；肝转移组的血脂水平高于非肝转移组，差异有统计学意义(P < 0.05)；多元Logistic回归分析显示：高三酰甘油血症及高膽固醇血症均为结直肠癌发生肝转移的独立危险因素(P < 0.05)，且与高密度脂蛋白及低密度脂蛋白的异常无关(P > 0.05)。 结论 高胆固醇及三酰高甘油水平可能促进结直肠癌的肝转移。
[关键词] 血脂异常；结直肠癌；肝转移；高甘油三脂血症；高胆固醇血症
[中图分类号] R735.3 [文献标识码] A [文章编号] 1673-7210(2017)06(b)-0092-04
Study on relationship between abnormality of blood lipid level and liver metastasis of colorectal
ZHANG Rui
Department of General Surgery， Chinese Medicine Hospital of Baoji City， Shaanxi Province， Baoji 721001， China
[Abstract] Objective To investigate the relationship between colorectal cancer patients with liver metastases and abnormal blood lipid levels. Methods From June 2008 to March 2016， in Department of General Surgery and Department of Anorectal Surgery， Chinese Medicine Hospital of Baoji City， the clinical data of 336 patients with colorectal cancer were analyzed retrospectively. They were divided into coloractal cancer with liver metastases group (52 cases) and colorectal cancer without liver metastases group (284 cases). The clinical data and initial blood lipid levels of colorectal cancer were analyzed and compared， the relationship of colorectal cancer with liver metastases patients and lipid levels， abnormal blood lipids was analyzed statistically. Results There were statistically significant differences in the depth of tumor invasion， regional lymph node metastasis and tumor differentiation degree between the two groups (P < 0.05). There was no statistically significant differences in the primary CEA level between the two groups (P > 0.05). The blood lipid levels of colorectal cancer with liver metastases group were higher than the colorectal cancer without liver metastases group， the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that hypertriglyceridemia and hypercholesterolemia were both independent risk factors with liver metastasis in colorectal cancer (P < 0.05)， but it had no association with high density lipoprotein and low density lipoprotein (P > 0.05). Conclusion High cholesterol and high triglyceride levels may promote liver metastasis in colorectal cancer.
[Key words] Abnormal blood lipid； Colorectal cancer； Liver metastases； High glycerin three greases； High cholesterol, http://www.100md.com(张锐)
[关键词] 血脂异常；结直肠癌；肝转移；高甘油三脂血症；高胆固醇血症
[中图分类号] R735.3 [文献标识码] A [文章编号] 1673-7210(2017)06(b)-0092-04
Study on relationship between abnormality of blood lipid level and liver metastasis of colorectal
ZHANG Rui
Department of General Surgery， Chinese Medicine Hospital of Baoji City， Shaanxi Province， Baoji 721001， China
[Abstract] Objective To investigate the relationship between colorectal cancer patients with liver metastases and abnormal blood lipid levels. Methods From June 2008 to March 2016， in Department of General Surgery and Department of Anorectal Surgery， Chinese Medicine Hospital of Baoji City， the clinical data of 336 patients with colorectal cancer were analyzed retrospectively. They were divided into coloractal cancer with liver metastases group (52 cases) and colorectal cancer without liver metastases group (284 cases). The clinical data and initial blood lipid levels of colorectal cancer were analyzed and compared， the relationship of colorectal cancer with liver metastases patients and lipid levels， abnormal blood lipids was analyzed statistically. Results There were statistically significant differences in the depth of tumor invasion， regional lymph node metastasis and tumor differentiation degree between the two groups (P < 0.05). There was no statistically significant differences in the primary CEA level between the two groups (P > 0.05). The blood lipid levels of colorectal cancer with liver metastases group were higher than the colorectal cancer without liver metastases group， the differences were statistically significant (P < 0.05). Multivariate Logistic regression analysis showed that hypertriglyceridemia and hypercholesterolemia were both independent risk factors with liver metastasis in colorectal cancer (P < 0.05)， but it had no association with high density lipoprotein and low density lipoprotein (P > 0.05). Conclusion High cholesterol and high triglyceride levels may promote liver metastasis in colorectal cancer.
[Key words] Abnormal blood lipid； Colorectal cancer； Liver metastases； High glycerin three greases； High cholesterol, http://www.100md.com(张锐)