中老年人群糖尿病前期血脂特点研究(1)
[摘要] 目的 探討中老年人群糖尿病前期血脂特点。 方法 选取2014年1月～2016年12月北京航天总医院内分泌科收治的中老年糖尿病前期患者270例作为研究对象，入院后完善相关检查，根据血糖检查结果分为空腹血糖受损(IFG)组(n=50)、糖耐量异常(IGT)组(n=120)及IFG+IGT组(n=100)，对3组血脂水平进行测定，患者均给予相应的治疗，连续对患者进行3年随访后再次测定血脂水平，比较3组血脂水平、血脂异常患病率及3年后的转归情况。 结果 3组干预前低密度脂蛋白(LDL-C)水平比较差异无统计学意义(P > 0.05)；IFG+IGT组干预前总胆固醇(TC)、三酰甘油(TG)水平均高于IFG组和IGT组(P < 0.05)；IFG+IGT组与IGT组干预前高密度脂蛋白(HDL-C)水平低于IFG组(P < 0.05)。IFG+IGT组干预前高TG血症发生率均高于IFG组及IGT组(P < 0.05)，IGT组干预前高TG血症发生率高于IFG组(P < 0.05)。3组干预后随访TC、TG、HDL-C及LDL-C水平比较差异无统计学意义(P > 0.05)。 结论 中老年人群糖尿病前期常伴有不同程度的脂代谢异常，加强TG水平监测能预测患者病情变化，指导临床治疗，改善患者预后。
[关键词] 中老年人群；糖尿病；血脂特点；影响
[中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210(2017)09(c)-0078-03
[Abstract] Objective To investigate the characteristics of blood lipid in prediabetes in middle-aged and elderly population. Methods From January 2014 to December 2016 admitted to Department of Endocrinology of Beijing Aerospace Hospital in elderly patients with prediabetes of 270 cases as research objects. The relevant examination after admission was perfected. According to the blood glucose test results， all patients were divided into fasting glucose group (IFG) group (n=50)， impaired glucose tolerance (IGT) group (n=120) and IFG+IGT group (n=100). The blood lipid levels of 3 groups were measured. The patients were given corresponding treatment， for 3 consecutive years of follow-up after lipid levels， blood lipid levels and blood lipid among 3 groups and the prevalence of abnormal outcome after 3 years. Results There was no significant difference among 3 groups in the level of LDL-C before intervention (P > 0.05). TC， TG levels in IFG+IGT group were higher than those in IFG group and IGT group before intervention (P < 0.05). The levels of high-density lipoprotein (HDL-C) in IFG+IGT group and IGT group were lower than those in IFG group before intervention (P < 0.05). The incidence of hyperglycemia in IFG+IGT group was significantly higher than that in IFG group and IGT group before intervention (P < 0.05). The incidence of hyperglycemia in IGT group was significantly higher than that in IFG group before intervention (P < 0.05). There was no significant difference in the levels of TC， TG， HDL-C and LDL-C among three groups (P > 0.05). Conclusion In the middle-aged and elderly people， prediabetes is often associated with different levels of lipid metabolism abnormalities. The monitoring of TG levels can predict the changes of patients' condition， guide clinical treatment and improve the prognosis of patients., http://www.100md.com(郭彩红 鲁辛 王瑞清)
[关键词] 中老年人群；糖尿病；血脂特点；影响
[中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210(2017)09(c)-0078-03
[Abstract] Objective To investigate the characteristics of blood lipid in prediabetes in middle-aged and elderly population. Methods From January 2014 to December 2016 admitted to Department of Endocrinology of Beijing Aerospace Hospital in elderly patients with prediabetes of 270 cases as research objects. The relevant examination after admission was perfected. According to the blood glucose test results， all patients were divided into fasting glucose group (IFG) group (n=50)， impaired glucose tolerance (IGT) group (n=120) and IFG+IGT group (n=100). The blood lipid levels of 3 groups were measured. The patients were given corresponding treatment， for 3 consecutive years of follow-up after lipid levels， blood lipid levels and blood lipid among 3 groups and the prevalence of abnormal outcome after 3 years. Results There was no significant difference among 3 groups in the level of LDL-C before intervention (P > 0.05). TC， TG levels in IFG+IGT group were higher than those in IFG group and IGT group before intervention (P < 0.05). The levels of high-density lipoprotein (HDL-C) in IFG+IGT group and IGT group were lower than those in IFG group before intervention (P < 0.05). The incidence of hyperglycemia in IFG+IGT group was significantly higher than that in IFG group and IGT group before intervention (P < 0.05). The incidence of hyperglycemia in IGT group was significantly higher than that in IFG group before intervention (P < 0.05). There was no significant difference in the levels of TC， TG， HDL-C and LDL-C among three groups (P > 0.05). Conclusion In the middle-aged and elderly people， prediabetes is often associated with different levels of lipid metabolism abnormalities. The monitoring of TG levels can predict the changes of patients' condition， guide clinical treatment and improve the prognosis of patients., http://www.100md.com(郭彩红 鲁辛 王瑞清)