[摘要] 1型糖尿病(T1DM)是具有遗传倾向的自身免疫性疾病，发病率逐年递增，其发病机制较为复杂且尚未完全阐明，涉及到T淋巴细胞和多种固有免疫细胞的相互调控。免疫细胞攻击胰岛β-细胞使其损伤或减少被认为是T1DM的主要致病因素。目前的治疗方法也有各自的局限，包括传统的胰岛素注射、胰岛移植，以及近年来的免疫治疗和干细胞治疗等方法。随着对T1DM发病机制的深入研究，将为T1DM的防治提供更为有效的靶点和方法。

    [关键词] 1型糖尿病；胰岛β-细胞；淋巴细胞；固有免疫细胞

    [中图分类号] R58 [文献标识码] A [文章编号] 1673-7210(2017)11(b)-0039-04

    [Abstract] Type 1 diabetes mellitus (T1DM) is a kind of autoimmune disease with genetic predisposition and its incidence is gradually increasing. The pathogenesis is relatively complicated and not yet fully elucidated. It relates the mutual regulation of T lymphocytes and a variety of innate immune cells. Immune cells attack the islet beta cells reduce its damage which is regarded as a main pathogenic factor of T1DM. The current treatments of T1DM ......