单、双相抑郁患者血浆非酶类抗氧化物和甲状腺激素水平研究(1)
[摘要] 目的 探討单、双相抑郁患者血浆非酶类抗氧化物以及甲状腺激素水平的变化及临床意义。 方法 选择2016年2～12月在武汉大学人民医院精神科住院的101例单相抑郁患者(单相抑郁组)、103例双相抑郁患者(双相抑郁组)以及85例健康对照者为研究对象(对照组)，根据入组时的问卷及汉密顿抑郁量表评分将单相抑郁组及双相抑郁组患者分别分为消极组和非消极组。检测并比较各组血浆非酶类抗氧化物(血浆尿酸、血浆白蛋白和血浆总胆红素)以及甲状腺激素[游离三碘甲状腺原氨酸(FT3)，游离甲状腺素(FT4)，促甲状腺激素(TSH)]的水平。 结果 双相抑郁组患者血尿酸水平明显高于单相抑郁患者和对照组，单相抑郁患者血尿酸水平低于对照组，单相抑郁组及双相抑郁组白蛋白和总胆红素水平均低于对照组，且双相抑郁组总胆红素水平低于单相抑郁组，差异均有统计学意义(P < 0.05)。单相抑郁组FT3水平明显低于双相抑郁组和正常对照组，差异均有统计学意义(P < 0.05)；三组FT4、TSH水平差异无统计学意义(P > 0.05)；单相抑郁组中非消极组FT3水平明显低于消极组，差异有统计学意义(P < 0.05)。 结论 单、双相抑郁患者体内存在明显的尿酸及白蛋白等非酶类抗氧化剂及甲状腺功能的异常，且血浆尿酸含量有望成为单、双相抑郁患者鉴别的一个辅助参考指标。
[关键词] 尿酸；甲状腺激素；总胆红素；白蛋白；抑郁
[中图分类号] R749.4 [文献标识码] A [文章编号] 1673-7210(2018)03(b)-0100-04
Study of plasma non-enzyme antioxidants and thyroid hormone levels in patients with unipolar and bipolar depression
FU Linyan LIU Zhongchun XIANG Dan XIAO Jiawei
Mental Health Center， Renmin Hospital of Wuhan University， Hubei Province， Wuhan 430060， China
[Abstract] Objective To explore the changes of plasma nonenzyme antioxidants and levels of thyroid hormone and their clinical significance in patients with unipolar and bipolar depression. Methods One hundred and one patients with unipolar depression (unipolar depression group)， 103 patients with bipolar depression (bipolar depression group) and 85 healthy controls (control group) were enrolled in the Renmin Hospital of Wuhan University from February 2016 to December 2016. According to the questionnaire and Hamilton depression scale， patients of the unipolar depression group and bipolar depression group were divided into negative and non-negative groups respectively. Serum levels of uric acid， albumin， total bilirubin， free triiodothyronine (FT3)， free thyroxine (FT4) and hemosiderin (TSH) of each group were measured and compared. Results The levels of uric acid in the bipolar depression group were significantly higher than that in the unipolar depression and control group， the level of uric acid in the unipolar depression group was lower than that of the control group， the levels of albumin and total bilirubin in the unipolar depression group and bipolar depression group were significantly lower than control group， and the both unipolar and bipolar depression group. The level of FT3 in the unipolar depression group was significantly lower than that in the bipolar depression group and the control group， there was no statistically significant difference in FT4， TSH among the three groups (P > 0.05). The level of FT3 in the non-negative groups was significantly lower than that in the negative group， the difference was statistically significant (P < 0.05). Conclusion Serum uric acid， albumin， total bilirubin and thyroid hormone levels are altered in patients with unipolar and bipolar depression， and the level of serum uric acid can be used as an auxiliary reference index for the differential diagnosis between unipolar and bipolar depression., 百拇医药(付林燕 刘忠纯 相丹 肖佳维)
[关键词] 尿酸；甲状腺激素；总胆红素；白蛋白；抑郁
[中图分类号] R749.4 [文献标识码] A [文章编号] 1673-7210(2018)03(b)-0100-04
Study of plasma non-enzyme antioxidants and thyroid hormone levels in patients with unipolar and bipolar depression
FU Linyan LIU Zhongchun XIANG Dan XIAO Jiawei
Mental Health Center， Renmin Hospital of Wuhan University， Hubei Province， Wuhan 430060， China
[Abstract] Objective To explore the changes of plasma nonenzyme antioxidants and levels of thyroid hormone and their clinical significance in patients with unipolar and bipolar depression. Methods One hundred and one patients with unipolar depression (unipolar depression group)， 103 patients with bipolar depression (bipolar depression group) and 85 healthy controls (control group) were enrolled in the Renmin Hospital of Wuhan University from February 2016 to December 2016. According to the questionnaire and Hamilton depression scale， patients of the unipolar depression group and bipolar depression group were divided into negative and non-negative groups respectively. Serum levels of uric acid， albumin， total bilirubin， free triiodothyronine (FT3)， free thyroxine (FT4) and hemosiderin (TSH) of each group were measured and compared. Results The levels of uric acid in the bipolar depression group were significantly higher than that in the unipolar depression and control group， the level of uric acid in the unipolar depression group was lower than that of the control group， the levels of albumin and total bilirubin in the unipolar depression group and bipolar depression group were significantly lower than control group， and the both unipolar and bipolar depression group. The level of FT3 in the unipolar depression group was significantly lower than that in the bipolar depression group and the control group， there was no statistically significant difference in FT4， TSH among the three groups (P > 0.05). The level of FT3 in the non-negative groups was significantly lower than that in the negative group， the difference was statistically significant (P < 0.05). Conclusion Serum uric acid， albumin， total bilirubin and thyroid hormone levels are altered in patients with unipolar and bipolar depression， and the level of serum uric acid can be used as an auxiliary reference index for the differential diagnosis between unipolar and bipolar depression., 百拇医药(付林燕 刘忠纯 相丹 肖佳维)