健脑止抽颗粒联合硫必利治疗儿童抽动秽语综合征的效果(1)
[摘要] 目的 观察健脑止抽颗粒联合硫必利治疗儿童抽动-秽语综合征(TS)的临床效果。 方法 收集2015年3～11月在首都儿科研究所附属儿童医院门诊诊治的TS患儿，按区组化随机分为对照组与治疗组，每组各30例。对照组患儿单独采用硫必利治疗，治疗组患儿采用硫必利和健脑止抽颗粒联合治疗，均治疗12周。记录两组患儿硫必利每日服用剂量，比较两组患儿治疗前后耶鲁综合抽动严重程度量表(YGTSS)评分和治疗有效率。 结果 治疗组患儿硫必利每日服用剂量低于对照组患儿(P < 0.05)。两组患儿治疗4、8、12周后的YGTSS评分均低于同组内治疗前YGTSS评分(P < 0.05)，且治疗组治疗后YGTSS评分均低于同期对照组(P < 0.05)。两组患儿治疗有效率比较，差异无统计学意义(P > 0.05)。 结论 与单纯采用硫必利治疗相比，健脑止抽颗粒联合硫必利没有明显提高TS患儿的治疗有效率，但能减少硫必利每日服用剂量，明显降低YGTSS评分。
[关键词] 儿童抽动-秽语综合征；健脑止抽颗粒；硫必利
[中图分类号] R749.94 [文献标识码] A [文章编号] 1673-7210(2018)06(b)-0065-04
[Abstract] Objective To observe the clinical efficacy of combination therapy with Jiannao Zhichou Granules and Tiapride in children with Tourette syndrome (TS). Methods Children with TS diagnosed in outpatient of Children′s Hospital affiliated to Children′s Hospital， Capital Institute of Pediatrics were collected from March to November in 2015， which were randomly divided into treatment group and control group， with 30 cases in each group. The control group was treated with monotherapy of Tiapride， and the treatment group was treated with combination therapy with Jiannao Zhichou Granules and Tiapride. They were treated for 12 weeks. The daily dosage of Tiapride in the two groups were recorded， the Yale global tic severity scale (YGTSS) before and after treatment and the treatment efficiency in the two groups were compared. Results The daily dosage of Tiapride in the treatment group was lower than that in the control group (P < 0.05). The YGTSS scores at 4， 8 and 12 weeks after treatment in both groups were lower than that before treatment in the same group (P < 0.05)， besides after treatment， the YGTSS scores in the treatment group at 4， 8 and 12 weeks after treatment were lower than those in the control group at the same time (P < 0.05). There was no statistically significant difference between the two groups in treatment efficiency (P > 0.05). Conclusion Combination therapy with Jiannao Zhichou Granules and Tiapride cannot significantly improve the treatment efficiency， while it can reduce the daily dosage of Tiapride and the YGTSS score clearly， compared with monotherapy of Tiapride.
[Key words] Tourette syndrome； Jiannao Zhichou Granule； Tiapride
抽動-秽语综合征(tourette syndrome，TS)是一种以儿童多见、抽动障碍为主要表现的慢性神经精神障碍性疾病，抽动障碍主要表现为不自主的突发、重复、快速、非节律性、呆板的单一或多组肌肉的运动型抽动和/或发声型抽动[1-2]。TS的发病与遗传、免疫及环境和神经递质失衡等多种因素有关[3-4]，具体机制尚不明确。目前西医主要通过药物治疗控制临床症状，主要以多巴胺受体阻滞剂、中枢神经抑制剂及抗精神病、抗癫痫药物为主；虽有一定的临床疗效，但常常伴有一定副作用，如帕金森症状、迟发性运动障碍、睡眠增多、代谢紊乱等，并且停药后易复发。近年来，临床采用中医药治疗TS的报道逐渐增多，显示了其独特的优势[5-7]。本研究采用中成药健脑止抽颗粒结合西药硫必利治疗TS，以期减少西药硫必利的使用剂量，提高临床效果，为临床用药提供参考。, http://www.100md.com(杨圣海 王立文 王珺 徐翠娟 宛付芹 )
[关键词] 儿童抽动-秽语综合征；健脑止抽颗粒；硫必利
[中图分类号] R749.94 [文献标识码] A [文章编号] 1673-7210(2018)06(b)-0065-04
[Abstract] Objective To observe the clinical efficacy of combination therapy with Jiannao Zhichou Granules and Tiapride in children with Tourette syndrome (TS). Methods Children with TS diagnosed in outpatient of Children′s Hospital affiliated to Children′s Hospital， Capital Institute of Pediatrics were collected from March to November in 2015， which were randomly divided into treatment group and control group， with 30 cases in each group. The control group was treated with monotherapy of Tiapride， and the treatment group was treated with combination therapy with Jiannao Zhichou Granules and Tiapride. They were treated for 12 weeks. The daily dosage of Tiapride in the two groups were recorded， the Yale global tic severity scale (YGTSS) before and after treatment and the treatment efficiency in the two groups were compared. Results The daily dosage of Tiapride in the treatment group was lower than that in the control group (P < 0.05). The YGTSS scores at 4， 8 and 12 weeks after treatment in both groups were lower than that before treatment in the same group (P < 0.05)， besides after treatment， the YGTSS scores in the treatment group at 4， 8 and 12 weeks after treatment were lower than those in the control group at the same time (P < 0.05). There was no statistically significant difference between the two groups in treatment efficiency (P > 0.05). Conclusion Combination therapy with Jiannao Zhichou Granules and Tiapride cannot significantly improve the treatment efficiency， while it can reduce the daily dosage of Tiapride and the YGTSS score clearly， compared with monotherapy of Tiapride.
[Key words] Tourette syndrome； Jiannao Zhichou Granule； Tiapride
抽動-秽语综合征(tourette syndrome，TS)是一种以儿童多见、抽动障碍为主要表现的慢性神经精神障碍性疾病，抽动障碍主要表现为不自主的突发、重复、快速、非节律性、呆板的单一或多组肌肉的运动型抽动和/或发声型抽动[1-2]。TS的发病与遗传、免疫及环境和神经递质失衡等多种因素有关[3-4]，具体机制尚不明确。目前西医主要通过药物治疗控制临床症状，主要以多巴胺受体阻滞剂、中枢神经抑制剂及抗精神病、抗癫痫药物为主；虽有一定的临床疗效，但常常伴有一定副作用，如帕金森症状、迟发性运动障碍、睡眠增多、代谢紊乱等，并且停药后易复发。近年来，临床采用中医药治疗TS的报道逐渐增多，显示了其独特的优势[5-7]。本研究采用中成药健脑止抽颗粒结合西药硫必利治疗TS，以期减少西药硫必利的使用剂量，提高临床效果，为临床用药提供参考。, http://www.100md.com(杨圣海 王立文 王珺 徐翠娟 宛付芹 )