上海市浦江镇地区3239例女性HPV感染现状及亚型分析(1)
[摘要] 目的 探讨上海市浦江镇地区女性人乳头瘤病毒(HPV)的感染现状和亚型分布，为预防HPV感染及宫颈疾病的防治提供理论依据。 方法 对2015年5月～2017年10月在上海交通大学医学院附属仁济医院南院妇科门诊就诊的3239例健康女性患者进行HPV亚型检测。 结果 3239例女性患者中，HPV阳性例数为589例(阳性率为18.18%)。单一亚型感染449例，占所有感染的76.23%；双重亚型感染106例，占所有感染18.0%；多重亚型感染34例，占所有感染的5.77%。>50～60岁年龄组的HPV阳性感染率和HPV高危亚型感染阳性率最高，差异有高度统计学意义(P < 0.01)。最常见的感染型别是HPV52、16、58。 结论 上海市浦江镇地区女性HPV感染率较高，以高危型感染和单一亚型感染为主，最常见的感染亚型为HPV52、16、58，应为该地区感染预防的重点。
[关键词] 人乳头瘤病毒；宫颈癌；HPV亚型；上海浦江镇
[中图分类号] R711.7 [文献标识码] A [文章编号] 1673-7210(2018)07(c)-0094-04
Analysis on the status and subtypes of HPV infection in 3239 females in Shanghai Pujiang District
XU Ya′nan XIAO Shijin LIU Wei▲
Department of Gynaecology and Obstetrics， South Campus of Renji Hospital， School of Medicine， Shanghai Jiaotong University， Shanghai 201112， China
[Abstract] Objective To investigate the infection status and genotype distribution of human papilloma virus (HPV) infection in Shanghai Pujiang District， and to provide a theoretical basis for the prevention of HPV infection and control of cervical lesions. Methods The detection results of cervical cytology screening for 3239 females in South Campus， Renji Hospital， School of Medicine， Shanghai Jiaotong University from May 2015 to October 2017 were collected， and the HPV typing data were analysed. Results 3239 cases of women were collected， 589 cases of women were HPV infected (the positive rate of HPV infection were 18.18%). There were 449 cases (76.23%) with single HPV type infection， 106 cases (18.0%) with double HPV subtypes infection and 34 cases (5.77%) with multiple HPV subtypes infection. >50-60 years women had the highest HPV infection rate and high-risk HPV subtype infection rate， the difference was statistically significant (P < 0.01). The most common subtypes were HPV52， 16， 58. Conclusion The HPV infection rate in Pujiang District is high， which mainly caused by single HPV genotypes and high-risk HPV subtypes. The most common subtype was HPV52， 16， 58. It is necessary to lay emphasis on preventing HPV52， 16， 58 infection for females in this area.
[Key words] Human papillpma virus； Cervical cancer； HPV subtype； Shanghai Pujiang District
宮颈癌是常见的妇科恶性肿瘤，位居全球女性病死率第二位，严重威胁着女性的生命健康[1]。人乳头瘤病毒(human papilloma virus，HPV)感染与宫颈癌发生密切相关，尤其是高危型HPV持续感染是导致宫颈癌发生的主要原因[2-4]。根据相关研究资料显示，HPV的感染率及常见基因亚型的分布在不同国家、不同地区存在明显的差异[5-7]。因此，了解HPV的感染情况及其亚型的分布，根据HPV分型结果采取不同的诊治方案，对宫颈癌的预防和治疗具有重要的临床意义。本研究对上海市闵行区浦江镇地区3239例女性感染HPV的情况进行检测和亚型分析，旨在了解本地区宫颈病变患者中的主要HPV亚型分布情况，为临床宫颈癌的筛查和防治提供理论依据。, 百拇医药(徐亚楠 肖世金 刘伟)
[关键词] 人乳头瘤病毒；宫颈癌；HPV亚型；上海浦江镇
[中图分类号] R711.7 [文献标识码] A [文章编号] 1673-7210(2018)07(c)-0094-04
Analysis on the status and subtypes of HPV infection in 3239 females in Shanghai Pujiang District
XU Ya′nan XIAO Shijin LIU Wei▲
Department of Gynaecology and Obstetrics， South Campus of Renji Hospital， School of Medicine， Shanghai Jiaotong University， Shanghai 201112， China
[Abstract] Objective To investigate the infection status and genotype distribution of human papilloma virus (HPV) infection in Shanghai Pujiang District， and to provide a theoretical basis for the prevention of HPV infection and control of cervical lesions. Methods The detection results of cervical cytology screening for 3239 females in South Campus， Renji Hospital， School of Medicine， Shanghai Jiaotong University from May 2015 to October 2017 were collected， and the HPV typing data were analysed. Results 3239 cases of women were collected， 589 cases of women were HPV infected (the positive rate of HPV infection were 18.18%). There were 449 cases (76.23%) with single HPV type infection， 106 cases (18.0%) with double HPV subtypes infection and 34 cases (5.77%) with multiple HPV subtypes infection. >50-60 years women had the highest HPV infection rate and high-risk HPV subtype infection rate， the difference was statistically significant (P < 0.01). The most common subtypes were HPV52， 16， 58. Conclusion The HPV infection rate in Pujiang District is high， which mainly caused by single HPV genotypes and high-risk HPV subtypes. The most common subtype was HPV52， 16， 58. It is necessary to lay emphasis on preventing HPV52， 16， 58 infection for females in this area.
[Key words] Human papillpma virus； Cervical cancer； HPV subtype； Shanghai Pujiang District
宮颈癌是常见的妇科恶性肿瘤，位居全球女性病死率第二位，严重威胁着女性的生命健康[1]。人乳头瘤病毒(human papilloma virus，HPV)感染与宫颈癌发生密切相关，尤其是高危型HPV持续感染是导致宫颈癌发生的主要原因[2-4]。根据相关研究资料显示，HPV的感染率及常见基因亚型的分布在不同国家、不同地区存在明显的差异[5-7]。因此，了解HPV的感染情况及其亚型的分布，根据HPV分型结果采取不同的诊治方案，对宫颈癌的预防和治疗具有重要的临床意义。本研究对上海市闵行区浦江镇地区3239例女性感染HPV的情况进行检测和亚型分析，旨在了解本地区宫颈病变患者中的主要HPV亚型分布情况，为临床宫颈癌的筛查和防治提供理论依据。, 百拇医药(徐亚楠 肖世金 刘伟)