[摘要] 他克莫司为大环内酯类新型免疫抑制剂，可抑制钙调磷酸酶的活性及阻止多种细胞因子生成，从而抑制T淋巴细胞活化，发挥药理作用。他克莫司在临床上应用广泛，本文通过明确其药理作用、疗效、不良反应，为临床安全用药奠定良好的基础。

    [关键词] 他克莫司；环孢素A；免疫抑制剂；进展

    [中图分类号] R969 [文献标识码] A [文章编号] 1673-7210(2018)09(c)-0026-04

    [Abstract] Tacrolimus is a new type immunosuppressant of macrolides， which inhibits the activity of calcium phosphatase and prevents the formation of various cytokines， so as to inhibit T lymphocyte activation to play pharmacological action. Tacrolimus is widely used in clinical practice ......