血清空腹C—肽水平与2型糖尿病患者血管病变的关系(1)
[摘要] 目的 探討血清空腹C-肽(FCP)水平与2型糖尿病(T2DM)患者血管病变的关系。 方法 回顾性分析2016年3月～2018年2月南京航空航天大学医院收治的105例T2DM患者，根据双下肢彩色多普勒检查结果将患者分为无血管病变组(52例)和血管病变组(53例)。比较两组患者一般资料、各项生化指标[空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbAlc)、FCP、餐后2 h C-肽(CP)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平，采用多因素Logistic回归分析T2DM患者的影响因素。 结果 血管病变组年龄、病程、高血压例数均较无血管病变组高，差异有统计学意义(P < 0.05)。血管病变组FBG、PBG、HbAlc、LDL-C显著高于无血管病变组，差异有统计学意义(P < 0.05)；而FCP、CP、HDL-C显著低于无血管病变组，差异有统计学意义(P < 0.05)。Logistic回归分析结果显示，年龄(≥50岁)、糖尿病病程(≥5年)、PBG(≥17 mmol/L)、HbAlc(≥9%)、LDL-C(≥3 mmol/L)为影响T2DM患者血管病变的独立危险因素，而FCP(>0.9 μg/L)、CP(>2.1 μg/L)为血管病变的保护因素(P > 0.05)。 结论 FCP可能对血管有保护作用，FCP的降低可能是T2DM患者血管病变发生、发展的原因之一。
[关键词] C-肽；2型糖尿病；血管病变；相关性
[中图分类号] R587 [文献标识码] A [文章编号] 1673-7210(2018)10(c)-0058-04
[Abstract] Objective To investigate the relationship between serum fasting C-peptide (FCP) and vascular disease in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective analysis of 105 patients with T2DM admitted to School Hospital of Nanjing University of Aeronautics & Astronautics from March 2016 to February 2018 was conducted. According to the results of color doppler examination of the lower limbs， the patients were divided into non vascular lesion group (52 cases) and vascular lesion group (53 cases). The general data of the two groups， biochemical indices including fasting blood glucose (FBG)， postprandial 2 h blood sugar (PBG)， glycated hemoglobin (HbAlc)， FCP， postprandial 2 h C-peptide (CP)， triglyceride (TG)， total cholesterol (TC)， low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared between the two groups. Multiple Logistic regression analysis was used to analyze the influencing factors of T2DM patients. Results The age， course and hypertension case number in vascular lesion group was higher than those in non vascular lesion group， and the differences between the two groups were statistically significant (P < 0.05). FBG， PBG， HbAlc and LDL-C in vascular lesion group was significantly higher than those in non vascular lesion group， and the differences were statistically significant (P < 0.05). While FCP， CP and HDL-C were significantly lower than those in non vascular lesion group， and the differences between the two groups were statistically significant (P < 0.05). The results of Logistic regression analysis showed that age (≥50 years)， diabetes course (≥5 years)， PBG (≥17 mmol/L)， HbA1c (≥9%)， and LDL-C (≥3 mmol/L) was independent risk factors of vascular lesions in T2DM， and FCP (>0.9 μg/L) and CP (> 2.1 μg/L) was protective factors of vascular lesions (P < 0.05). Conclusion FCP may protect the blood vessels， and the decrease of FCP may be one of the reasons for the occurrence and development of vascular disease in T2DM patients., http://www.100md.com(屈小燕 方爱娟 孙丽君 沈山梅)
[关键词] C-肽；2型糖尿病；血管病变；相关性
[中图分类号] R587 [文献标识码] A [文章编号] 1673-7210(2018)10(c)-0058-04
[Abstract] Objective To investigate the relationship between serum fasting C-peptide (FCP) and vascular disease in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective analysis of 105 patients with T2DM admitted to School Hospital of Nanjing University of Aeronautics & Astronautics from March 2016 to February 2018 was conducted. According to the results of color doppler examination of the lower limbs， the patients were divided into non vascular lesion group (52 cases) and vascular lesion group (53 cases). The general data of the two groups， biochemical indices including fasting blood glucose (FBG)， postprandial 2 h blood sugar (PBG)， glycated hemoglobin (HbAlc)， FCP， postprandial 2 h C-peptide (CP)， triglyceride (TG)， total cholesterol (TC)， low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared between the two groups. Multiple Logistic regression analysis was used to analyze the influencing factors of T2DM patients. Results The age， course and hypertension case number in vascular lesion group was higher than those in non vascular lesion group， and the differences between the two groups were statistically significant (P < 0.05). FBG， PBG， HbAlc and LDL-C in vascular lesion group was significantly higher than those in non vascular lesion group， and the differences were statistically significant (P < 0.05). While FCP， CP and HDL-C were significantly lower than those in non vascular lesion group， and the differences between the two groups were statistically significant (P < 0.05). The results of Logistic regression analysis showed that age (≥50 years)， diabetes course (≥5 years)， PBG (≥17 mmol/L)， HbA1c (≥9%)， and LDL-C (≥3 mmol/L) was independent risk factors of vascular lesions in T2DM， and FCP (>0.9 μg/L) and CP (> 2.1 μg/L) was protective factors of vascular lesions (P < 0.05). Conclusion FCP may protect the blood vessels， and the decrease of FCP may be one of the reasons for the occurrence and development of vascular disease in T2DM patients., http://www.100md.com(屈小燕 方爱娟 孙丽君 沈山梅)