急性心肌梗死患者血清EMPs、hs-CRP变化及临床意义(1)
[摘要] 目的 探讨急性心肌梗死(AMI)患者血清内皮微颗粒(EMPs)、超敏C反应蛋白(hs-CRP)水平变化及其临床意义。 方法 选取2016年1月～2018年1月在西安交通大学第二附属医院(以下简称“我院”)住院治疗的AMI患者146例作为观察组，另选同期在我院治疗的存在室性期前收缩的非AMI患者50例作为对照组。检测并比较两组患者的血清EMPs、hs-CRP水平;采用Gensini评分评价观察组患者血管狭窄程度;应用冠状动脉造影检测观察组患者血管病变支数;比较不同Gensini评分和血管病变支数患者的血清EMPs、hs-CRP水平，分析血清EMPs、hs-CRP水平与Gensini评分及冠状动脉病变支数的相关性。 结果 观察组血清EMPs、hs-CRP水平均明显高于对照组，差异有统计学意义(P < 0.05)。观察组血清EMPs、hs-CRP水平随着Gensini评分的升高而逐渐升高，差异有统计学意义(P < 0.05)。观察组血清EMPs、hs-CRP水平随着血管病变支数的增加而逐渐升高，差异有统计学意义(P < 0.05)。观察组血清EMPs、hs-CRP水平与Gensini评分及冠状动脉病变支数均呈正相关(EMPs：r = 0.583、0.527，P < 0.05;hs-CRP：r = 0.634、0.582，P < 0.05)。 结论 AMI患者血清EMPs、hs-CRP水平异常升高，且其水平与患者冠状动脉严重程度和累及范围密切相关。EMPs、hs-CRP或可成为判断AMI病情的标志物。
[关键词] 急性心肌梗死;内皮微颗粒;超敏C反应蛋白;Gensini评分;血管狭窄
[中圖分类号] R542.22 [文献标识码] A [文章编号] 1673-7210(2019)08(a)-0170-04
[Abstract] Objective To investigate the changes of serum endothelial-derived microparticles (EMPs) and hypersensitive C-reactive protein (hs-CRP) levels in patients with acute myocardial infarction (AMI) and its clinical significance. Methods A total of 146 patients with AMI hospitalized in the Second Affiliated Hospital of Xi′an Jiaotong University (“our hospital” for short) from January 2016 to January 2018 were selected as the observation group. Another 50 non-AMI patients with ventricular premature contractions who were treated in our hospital in the same period were selected as the control group. The levels of serum EMPs and hs-CRP were detected and compared between the two groups. Gensini score was used to evaluate the degree of vascular stenosis in the observation group， and coronary angiography was used to detect the number of vascular lesions in the observation group. The serum levels of EMPs and hs-CRP in patients with different Gensini score and vessel lesion branches were compared. The correlation between serum level of EMPs and hs-CRP and Gensini score and coronary artery lesion branches were analyzed. Results The levels of serum EMPs and hs-CRP in the observation group were higher than those in the control group， the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP in the observation group increased gradually with the increase of Gensini score， the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP in the observation group increased gradually with the increase of the number of vascular lesion branches， the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP were positively correlated with Gensini score and the number of coronary artery lesions (EMPs： r = 0.583， 0.527; P < 0.05， hs-CRP： r = 0.634， 0.582， P < 0.05). Conclusion The levels of serum EMPs and hs-CRP in patients with AMI are abnormally elevated， and their level are closely related to the severity and extent of coronary artery involvement. EMPs， hs-CRP may be used as markers for judging the severity of AMI., http://www.100md.com(袁晓红 李鹏 刘军辉)
[关键词] 急性心肌梗死;内皮微颗粒;超敏C反应蛋白;Gensini评分;血管狭窄
[中圖分类号] R542.22 [文献标识码] A [文章编号] 1673-7210(2019)08(a)-0170-04
[Abstract] Objective To investigate the changes of serum endothelial-derived microparticles (EMPs) and hypersensitive C-reactive protein (hs-CRP) levels in patients with acute myocardial infarction (AMI) and its clinical significance. Methods A total of 146 patients with AMI hospitalized in the Second Affiliated Hospital of Xi′an Jiaotong University (“our hospital” for short) from January 2016 to January 2018 were selected as the observation group. Another 50 non-AMI patients with ventricular premature contractions who were treated in our hospital in the same period were selected as the control group. The levels of serum EMPs and hs-CRP were detected and compared between the two groups. Gensini score was used to evaluate the degree of vascular stenosis in the observation group， and coronary angiography was used to detect the number of vascular lesions in the observation group. The serum levels of EMPs and hs-CRP in patients with different Gensini score and vessel lesion branches were compared. The correlation between serum level of EMPs and hs-CRP and Gensini score and coronary artery lesion branches were analyzed. Results The levels of serum EMPs and hs-CRP in the observation group were higher than those in the control group， the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP in the observation group increased gradually with the increase of Gensini score， the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP in the observation group increased gradually with the increase of the number of vascular lesion branches， the differences were statistically significant (P < 0.05). The levels of serum EMPs and hs-CRP were positively correlated with Gensini score and the number of coronary artery lesions (EMPs： r = 0.583， 0.527; P < 0.05， hs-CRP： r = 0.634， 0.582， P < 0.05). Conclusion The levels of serum EMPs and hs-CRP in patients with AMI are abnormally elevated， and their level are closely related to the severity and extent of coronary artery involvement. EMPs， hs-CRP may be used as markers for judging the severity of AMI., http://www.100md.com(袁晓红 李鹏 刘军辉)