理气活血汤联合西药治疗气滞血瘀型慢性前列腺炎的临床研究(1)
[摘要] 目的 探讨理气活血汤联合西药治疗气滞血瘀症慢性前列腺炎(CP)的临床效果。 方法 选取2018年4月～2019年5月无锡市第三人民医院收治的CP患者92例，采用随机数字表法将患者分为研究组(46例)和对照组(46例)。对照组给予常规西药治疗，研究组在对照组基础上联合理气活血汤治疗。比较两组患者临床效果、中医症候积分、炎性因子水平及不良反应发生情况。 结果 两组患者治疗8周后会阴部疼痛、尿后滴沥、会阴部坠胀、排尿刺痛等症状积分和前列腺液白细胞介素-8(IL-8)、γ-干扰素(IFN-γ)及肿瘤坏死因子-α(TNF-α)水平均显著低于治疗前，且研究组低于对照组，差异有統计学意义(P < 0.05)。研究组临床总有效率显著高于对照组，差异有统计学意义(P < 0.05)。两组患者不良反应发生率比较，差异无统计学意义(P > 0.05)。 结论 理气活血汤联合西药治疗气滞血瘀型CP患者，效果确切，可迅速改善患者临床症状，减轻机体炎性因子水平，且用药安全性较好。
[关键词] 理气活血汤;西药;气滞血瘀型;慢性前列腺炎;临床效果
[中图分类号] R969.4 [文献标识码] A [文章编号] 1673-7210(2019)12(c)-0123-04
[Abstract] Objective To explore the clinical effect of Liqi Huoxue Decoction combined with Western medicine on chronic prostatitis (CP) with stagnation of qi and blood stasis. Methods A total of 92 CP patients admitted to Wuxi Third People′s Hospital from April 2018 to March 2019 were divided into study group (46 cases) and control group (46 cases) by random number table method. The control group was treated with conventional Western medicine， while the study group was treated with Liqi Huoxue Decoction on the basis of the control group. The curative effect， traditional Chinese medicine symptom score， inflammatory factor levels and the incidence of adverse reactions were compared between the two groups. Results After 8 weeks of treatment， the symptom scores of perineum pain， post urine drip， perineum distention， urination tingling and the levels of interleukin-8 (IL-8)， interferon-γ (IFN-γ) and tumor necrosis factor -α (TNF-α) in prostatic fluid in the two groups were lower than before the treatment， while the study group were lower than those in the control group， and the differences were statistically significant (P < 0.05). The total clinical effective rate of the study group was significantly higher than that of the control group， and the difference was statistically significant (P < 0.05). There was no difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Liqi Huoxue Decoction combined with Western medicine is effective in the treatment of CP patients with the symptom of stagnation of qi and blood stasis. It can rapidly improve the clinical symptoms of the patients， reduce the levels of inflammatory factors in the body， and the drug is safety.
[Key words] Liqi Huoxue Decoction; Western medicine; The symptom of stagnation of qi and blood stasis; Chronic prostatitis; Clinical effect
慢性前列腺炎(CP)是指由各种病因引起的前列腺组织慢性炎症，多发于中年男性，是临床常见的泌尿系统性疾病[1]。据统计，全球男性CP发病率为10%～14%，且呈现逐年递增趋势[2]。临床主要表现为排尿异常及慢性盆腔疼痛，若未能及时予以治疗，会对患者性功能和生育功能造成一定影响，同时对患者心理也带来一定的压力，严重影响患者生活质量。以往临床常用的西药治疗虽可获得一定效果，但由于该病病因极其复杂，不易彻底治疗。此外，停药后极易复发，长期用药不良反应较大，效果仍有待提升。近年来，中西医结合治CP取得了较大的进展，中医认为CP属于“精浊”“劳淋”范畴，主因不外乎瘀血、肾虚、湿热，病程日久则气滞血瘀[3]。故中医认为治疗应以活血祛瘀散结、清热利湿化湿为宜。理气活血汤由当归、柴胡、川芎、陈皮、枳壳、香附、赤芍、白芍、熟地黄、红花、桃仁、牛膝、白蒺藜、炙甘草、蜈蚣等药材组方而成，可发挥活血理气、祛瘀消肿的功效[4]。现临床有关理气活血汤联合西药治疗气滞血瘀型CP相关报道并不十分多见，以此进行分析。, 百拇医药(秦锋 吴升 杨明月)
[关键词] 理气活血汤;西药;气滞血瘀型;慢性前列腺炎;临床效果
[中图分类号] R969.4 [文献标识码] A [文章编号] 1673-7210(2019)12(c)-0123-04
[Abstract] Objective To explore the clinical effect of Liqi Huoxue Decoction combined with Western medicine on chronic prostatitis (CP) with stagnation of qi and blood stasis. Methods A total of 92 CP patients admitted to Wuxi Third People′s Hospital from April 2018 to March 2019 were divided into study group (46 cases) and control group (46 cases) by random number table method. The control group was treated with conventional Western medicine， while the study group was treated with Liqi Huoxue Decoction on the basis of the control group. The curative effect， traditional Chinese medicine symptom score， inflammatory factor levels and the incidence of adverse reactions were compared between the two groups. Results After 8 weeks of treatment， the symptom scores of perineum pain， post urine drip， perineum distention， urination tingling and the levels of interleukin-8 (IL-8)， interferon-γ (IFN-γ) and tumor necrosis factor -α (TNF-α) in prostatic fluid in the two groups were lower than before the treatment， while the study group were lower than those in the control group， and the differences were statistically significant (P < 0.05). The total clinical effective rate of the study group was significantly higher than that of the control group， and the difference was statistically significant (P < 0.05). There was no difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Liqi Huoxue Decoction combined with Western medicine is effective in the treatment of CP patients with the symptom of stagnation of qi and blood stasis. It can rapidly improve the clinical symptoms of the patients， reduce the levels of inflammatory factors in the body， and the drug is safety.
[Key words] Liqi Huoxue Decoction; Western medicine; The symptom of stagnation of qi and blood stasis; Chronic prostatitis; Clinical effect
慢性前列腺炎(CP)是指由各种病因引起的前列腺组织慢性炎症，多发于中年男性，是临床常见的泌尿系统性疾病[1]。据统计，全球男性CP发病率为10%～14%，且呈现逐年递增趋势[2]。临床主要表现为排尿异常及慢性盆腔疼痛，若未能及时予以治疗，会对患者性功能和生育功能造成一定影响，同时对患者心理也带来一定的压力，严重影响患者生活质量。以往临床常用的西药治疗虽可获得一定效果，但由于该病病因极其复杂，不易彻底治疗。此外，停药后极易复发，长期用药不良反应较大，效果仍有待提升。近年来，中西医结合治CP取得了较大的进展，中医认为CP属于“精浊”“劳淋”范畴，主因不外乎瘀血、肾虚、湿热，病程日久则气滞血瘀[3]。故中医认为治疗应以活血祛瘀散结、清热利湿化湿为宜。理气活血汤由当归、柴胡、川芎、陈皮、枳壳、香附、赤芍、白芍、熟地黄、红花、桃仁、牛膝、白蒺藜、炙甘草、蜈蚣等药材组方而成，可发挥活血理气、祛瘀消肿的功效[4]。现临床有关理气活血汤联合西药治疗气滞血瘀型CP相关报道并不十分多见，以此进行分析。, 百拇医药(秦锋 吴升 杨明月)