[Key words] Magnetic resonance imaging; T2 relaxation time diagram; Diffusion tensor imaging; Knee cartilage

    膝关节骨性关节炎(knee osteoarthritis，KOA)是临床常见慢性骨关节病，晚期致残率极高。核磁共振成像(MRI)生理成像序列如T2弛豫时间图(T2-mapping)、扩散张量成像(diffusion tensor imaging，DTI)，弥散加权成像(diffusion weighted imaging，DWI)等能够对软骨损伤早期尚未出现形态学改变前进行诊断。本文通过对正常志愿者及KOA患者膝关节软骨T2-mapping值、表观弥散系数(apparent diffusion coefficient，ADC)值及部分各向异性系数(fractional anisotropic，FA)值进行测量与分析，探讨T2-mapping、DTI序列对膝关节慢性软骨损伤的定量诊断价值 ......