补阳还五汤联合强化降脂抗凝药治疗气虚血瘀证缺血性中风的效果(1)
[摘要] 目的 探討补阳还五汤联合强化降脂抗凝药治疗气虚血瘀证缺血性中风的效果。 方法 选取安徽省淮北市人民医院2015年12月—2019年12月收治的气虚血瘀证缺血性中风患者200例作为研究对象。采用随机数字表法将其分为两组，各100例。两组均给予降压、降糖、抗血小板聚集等常规药物治疗。对照组采用强化降脂抗凝治疗，观察组在此基础上联合补阳还五汤治疗，均治疗2周。治疗后，比较两组治疗效果，记录两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、中医证候积分、血清神经生长因子(NGF)、脑源性神经细胞营养因子(BDNF)水平及生活质量评分。 结果 观察组总有效率明显高于对照组，差异有统计学意义(P < 0.05)。两组治疗后的NIHSS评分、中医证候积分均低于治疗前，且观察组低于对照组，差异有统计学意义(P < 0.05)。两组治疗后的NGF、BDNF水平均高于治疗前，且观察组高于对照组，差异有统计学意义(P < 0.05)。两组治疗后的健康状况、生理功能、情感职能、社会功能评分均高于治疗前，且观察组高于对照组，差异有统计学意义(P < 0.05)。 结论 补阳还五汤联合强化降脂抗凝治疗气虚血瘀证缺血性中风的效果显著，可有效缓解患者临床症状，抑制血清NGF、BDNF表达水平，改善生活质量，可在临床推广使用。
[关键词] 缺血性中风;气虚血瘀证;补阳还五汤;强化降脂抗凝药;生活质量
[中图分类号] R277.7 [文献标识码] A [文章编号] 1673-7210(2020)08(a)-0127-05
[Abstract] Objective To explore the effect of Buyang Huanwu Decoction combined with enhanced lipid-lowering and anticoagulation in the treatment of ischemic stroke with syndrome of qi deficiency and blood stasis. Methods Two hundred patients of ischemic stroke with syndrome of qi deficiency and blood stasis admitted to Anhui Huaibei People′s Hospital from December 2015 to December 2019 were selected as research objects. Simple random number table method was used to divide the patients into two groups， with 100 cases in each group. Two groups were given antihypertensive， hypoglycemic， antiplatelet aggregation and other conventional treatment. Control group was treated with intensive lipid-lowering and anticoagulant therapy， and observation group was treated with Buyang Huanwu Decoction for two weeks. After treatment， the effect of two groups was compared. National Institute of Health stroke scale (NIHSS) score， traditional Chinese medicine syndrome score， serum nerve growth factor (NGF)， brain-derived neurotrophic factor (BDNF) level and quality of life score of two groups were recorded before and after treatment. Results Total effective rate of observation group was significantly higher than that of control group， the difference was statistically significant (P < 0.05). NIHSS score and traditional Chinese medicine syndrome score of two groups after treatment were lower than those before treatment， and observation group was lower than control group， the differences were statistically significant (P < 0.05). The levels of NGF and BDNF in two groups after treatment were higher than those before treatment， and observation group was higher than control group， the differences were statistically significant (P < 0.05). The scores of health status， physiological function， emotional function and social function of two groups after treatment were higher than those before treatment， and observation group was higher than control group， the differences were statistically significant (P < 0.05). Conclusion Buyang Huanwu Decoction combined with enhanced lipid-lowering and anticoagulation can effectively alleviate clinical symptoms of patients， inhibit the expression levels of serum NGF and BDNF， and improve the quality of life， which can be widely used in clinic., http://www.100md.com(徐莲)
[关键词] 缺血性中风;气虚血瘀证;补阳还五汤;强化降脂抗凝药;生活质量
[中图分类号] R277.7 [文献标识码] A [文章编号] 1673-7210(2020)08(a)-0127-05
[Abstract] Objective To explore the effect of Buyang Huanwu Decoction combined with enhanced lipid-lowering and anticoagulation in the treatment of ischemic stroke with syndrome of qi deficiency and blood stasis. Methods Two hundred patients of ischemic stroke with syndrome of qi deficiency and blood stasis admitted to Anhui Huaibei People′s Hospital from December 2015 to December 2019 were selected as research objects. Simple random number table method was used to divide the patients into two groups， with 100 cases in each group. Two groups were given antihypertensive， hypoglycemic， antiplatelet aggregation and other conventional treatment. Control group was treated with intensive lipid-lowering and anticoagulant therapy， and observation group was treated with Buyang Huanwu Decoction for two weeks. After treatment， the effect of two groups was compared. National Institute of Health stroke scale (NIHSS) score， traditional Chinese medicine syndrome score， serum nerve growth factor (NGF)， brain-derived neurotrophic factor (BDNF) level and quality of life score of two groups were recorded before and after treatment. Results Total effective rate of observation group was significantly higher than that of control group， the difference was statistically significant (P < 0.05). NIHSS score and traditional Chinese medicine syndrome score of two groups after treatment were lower than those before treatment， and observation group was lower than control group， the differences were statistically significant (P < 0.05). The levels of NGF and BDNF in two groups after treatment were higher than those before treatment， and observation group was higher than control group， the differences were statistically significant (P < 0.05). The scores of health status， physiological function， emotional function and social function of two groups after treatment were higher than those before treatment， and observation group was higher than control group， the differences were statistically significant (P < 0.05). Conclusion Buyang Huanwu Decoction combined with enhanced lipid-lowering and anticoagulation can effectively alleviate clinical symptoms of patients， inhibit the expression levels of serum NGF and BDNF， and improve the quality of life， which can be widely used in clinic., http://www.100md.com(徐莲)