[Key words] Rabdosia Rubescens; Metabolism-associated fatty liver disease; Peroxisome proliferator-activated receptor-α; Sterol regulatory element binding protein-1c; Fatty acid synthase; Acetyl-CoA carboxylase

    代谢相关脂肪性肝病(metabolic associated fatty liver disease，MAFLD)是一种与胰岛素抵抗(insulin resistance，IR)和遗传易感密切相关的代谢应激性肝损伤[1]。随着生活方式的改变和病毒性肝病的控制，MAFLD发病逐年增加，全球成人患病率约25%，已成为我国第一大慢性肝病(占慢性肝病的49.3%)，人群危害日益嚴重[2-3]。因此，深入对MAFLD的发病和发展机理研究 ......