[摘要]变异链球菌是人类龋病的主要致病菌，不仅在数量上优势明显，而且其产酸和耐酸能力较强，其生物膜黏附于牙表面是其毒性致龋的首要步骤。酪蛋白裂解酶P(ClpP)是细菌体内一种介导蛋白质水解的热休克蛋白，可清除细菌体内的变性蛋白质，影响细菌的生物膜形成并且在细菌对生存环境的诸多应激反应中发挥着一定的作用。本文就ClpP，变异链球菌ClpP，其他致病微生物的ClpP等研究进展作一综述。

    [关键词]变异链球菌；酪蛋白质裂解酶；应激反应；生物膜

    [中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.02.026

    Influence of the caseinolytic protease on the ability of Streptococcus mutans to cause dental cariesWang Tuo, Yu Danni.(Dept. of Stomatology, The Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China)

    [Abstract]Streptococcus mutans is known as a primary pathogen of dental caries, it not only has an advantage over amount, but also has a strong ability to produce and resist acid. However, forming biofilms to adhere to the surface of the teeth is the most important step. The caseinolytic protease is a kind of heat shock protein, which mediates the proteolysis. This protease can remove the denatured proteins in the bacterial and play a particular role in biofilm formation and stress response reaction of the bacterial.

    [Key words]Streptococcus mutans；caseinolytic protease；stress response；biofilm ......