[摘要]牙科铸造合金在口腔临床中被广泛应用，而合金修复后在长期使用过程中，由于口腔内复杂微环境的影响，合金在口腔中的腐蚀会引起金属离子析出。大量的研究发现：这些析出的金属离子会对邻近的组织和细胞带来不同程度的慢性毒副作用，主要包括局部不良反应和全身不良反应。由于全身不良反应的发生率较低，相关的数据报道也比较有限，所以对合金中析出的金属离子引起的口腔局部不良反应成为国内外学者研究的热点。本文就铸造合金析出的金属离子对组织和细胞的毒副作用的研究现状及相应的细胞调控机制作一综述。

    [关键词]牙科铸造合金；离子析出；细胞毒性；免疫反应；氧化应激

    [中图分类号]R 783.1[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.02.031

    Research progress on the cell regulation mechanisms of chronic toxicity of dental casting alloysZhao Fei, Wang Ge.[The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)＆Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatolgy, Wuhan University, Wuhan 430079, China]

    [Abstract]Dental casting alloys have been widely used in dental restorations. Due to the complex microenvironment in the mouth, the corrosion of dental casting alloys leads to the release of elements from alloys for prolonged time. Previous studies have shown that the release of ions from alloys is directly related to chronic adverse biological effects on the surrounding tissues and cells. The adverse effects contain local undesirable reactions and systemic symptoms, however, the dates available about the incidence of systemic symptoms are regarded as scarce, so the local adverse reactions of metal ions released from alloys have become the focus extensively investigated. This article addressed the toxic effects of metallic ions released from casting alloys as well as the cell regulation mechanisms are reviewed. ......