[摘要]牙周病是一种微生物感染导致的牙周组织炎症破坏性疾病，先天性免疫防御功能正常与否与牙周炎的发展转归息息相关。组织蛋白酶抑制素cathelicidin是一种内源性抗菌肽，人源阳离子抗菌肽(hCAP)-18和LL-37是迄今发现的唯一的cathelicidin家族成员，而前者是其前体形式，后者则是其有活性的成熟形式。本文就hCAP-18和LL-37，LL-37的功能，LL-37与牙周病的关系等研究进展作一综述。

    [关键词]LL-37；抗菌肽；组织蛋白酶抑制素；牙周病；先天免疫

    [中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.03.012

    Antimicrobial peptide LL-37 and its relationship between periodontal diseaseSu Ruiying1，2, Chen Shan-shan1，2, Zhao Lei2.(1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; 2. Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

    [Abstract]Periodontal disease is a chronic inflammatory disease that leads to destruction of the periodontium. The abnormal innate immune defense and outcome of periodontal disease is closely related. Cathelicidin is one of endogenous peptide, hCAP-18 and LL-37 is the only member of the cathelicidin family known to exist in human. The former is regarded as an inactive precursor, and the latter is the active mature form. In this review, we em-phasize on the hCAP-18, the function of LL-37 and its relationship between periodontal disease. ......