[摘要]牙髓干细胞(DPSC)是一种具有高度增生、自我更新能力和多相分化潜能的成体干细胞，在一定条件下可向特定的细胞类型分化，在牙髓修复和牙齿再生中发挥着重要的作用。本文主要就DPSC成骨向分化、成牙本质向分化的研究进展作一综述。

    [关键词]牙髓干细胞；成牙本质向分化；成骨向分化

    [中图分类号]Q 254[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.03.027

    Research progress on dental pulp stem cells differentiationGou Wenting, Ye Ling, Tan Hong.(Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

    [Abstract]Dental pulp stem cell(DPSC)is a kind of adult stem cells with high proliferative capacity, self-renewal property and multilineage differentiation potential, which are capable to differentiate into several lineages under specific stimuli and play an important role in dental pulp repair and tooth regeneration. This article will review the research progress of DPSC differentiation.

    [Key words]dental pulp stem cell；odontoblastic differentiation；osteogenic differentiation

    牙髓组织中具有形成细胞克隆能力和较强增殖能力的未分化间充质细胞即牙髓干细胞(dental pulp stem cell，DPSC)。微环境的变化，诱导了DPSC分化相关基因的程序化表达，使其增殖分化为不同类型的功能细胞。本文就DPSC分化相关的研究进展作一综述。

    1成牙本质向分化

    Gronthos等[1]发现：DPSC被L-维生素C和地塞米松诱导5～6周后可形成高密度散在的矿化结节；将DPSC复合到羟磷灰石/磷酸三钙支架上植入免疫缺陷小鼠皮下 ......