[摘要]微小RNA是非编码单链小分子RNA，通常在转录后水平通过降解抑制目标信使RNA参与基因调控，目前研究发现微小RNA与口腔癌关系密切，在某些口腔癌前疾病的癌变过程中发挥着重要作用，此文就微小RNA与口腔癌前病变的关系作一综述。

    [关键词]微小RNA；口腔癌前病变；口腔肿瘤

    [中图分类号]R 318[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.03.030

    Micro RNAs and oral premalignant lesionsZhu Xiaohan, Fu Ji, Chen Qianming, Zeng Xin.(Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

    [Abstract]Micro RNAs are small non-coding RNAs that mediate gene expression at the post-transcriptional level by degrading or repressing target messenger RNAs. The current studies showed micro RNAs were related to many oral cancers and played a key role in the tumorigenesis of some oral premalignant lesions. The relationship of mi-cro RNAs and oral premalignant lesions was reviewed in the article.

    [Key words]micro RNA；oral premalignant lesion；mouth neoplasm

    微小RNA(micro RNA，miRNA)是一种在进化上高度保守的非编码单链小分子RNA，由21~ 25个核苷酸组成，通常在转录后通过降解或抑制目标信使RNA(messenger RNA，mRNA)参与基因调控[1]。自1993年在线虫中发现以来，miRNA已被证实在生物发育、组织分化、细胞凋亡中发挥着重要作用[2]。近年来，miRNA在癌症的发生发展中的作用成为新的研究热点。有诸多报道论述了miRNA与肺癌[3]、乳腺癌[4]、结肠癌[5]等肿瘤的关系 ......