[摘要]正畸牙受矫治力作用后，其牙周组织将发生一系列的生物化学反应，多种细胞因子和激素参与了反应的整个过程。高速泳动族蛋白盒1(HMGB1)是一种重要的晚期炎症因子，参与骨组织改建并与成纤维细胞相互作用，据此推测其可能参与正畸牙移动过程中的牙周组织改建。本文就HMGB1与炎症反应、骨组织改建、成纤维细胞、牙周炎，正畸牙移动的生物学基础等研究现状作一综述。

    [关键词]高速泳动族蛋白盒1；骨改建；成纤维细胞；正畸牙；移动

    [中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.04.018

    The correlation research of the relationship between high mobility group protein box 1 and orthodontic tooth movementPeng Xinxin, Xu Linyu, Lan Zedong.(Dept. of Orthodontics, The Affiliated Stomatological Hos-pital of Fujian Medical University, Fuzhou 350002, China)

    [Abstract]A series of biochemical reaction happened in the periodontal tissue during orthodontic tooth movement, varies cytokine and hormone participate in the process. High mobility group protein box 1(HMGB1)is an important late inflammatory mediator. In recent years, researches have made to find that HMGB1 was involved in the remolding and metabolism of bone and can interacted with fibroblast. Because of the biological effect, we can speculate that HMGB1 may play an important role in the remolding of periodontal tissue during orthodontic tooth movement. This review focused on the relationship between HMGB1 and orthodontic tooth movement. ......