[摘要]骨关节炎是一种退行性病损，表现为关节软骨的破坏和软骨下骨的吸收或异常增生，细胞因子通过各种机制调节该过程中软骨细胞的活动。本文就相关细胞因子在骨关节炎软骨病变过程中的作用作一综述。

    [关键词]骨关节炎；软骨细胞；细胞因子；关节

    [中图分类号]R 782.6[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.04.020

    The role of cytokines in cartilage degeneration in osteoarthritisDai Kang, Jiao Kai, Wang Meiqing.(Dept. of Oral Anatomy and Physiology, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China)

    [Abstract]Osteoarthritis(OA)is a kind of degenerative disease characterized by the destruction of articular cartilage and the subchondral bone resorption or dysplasia. Cytokines regulate the functions of chondrocytes through various mechanisms. The actions of related cytokines in the pathogenesis of osteoarthritis cartilage were reviewed.

    [Key words]osteoarthritis；cartilage；cytokines；joint

    骨关节炎(osteoarthritis，OA)是一种累及软骨及软骨下骨的退行性病损，常与年龄、遗传、创伤以及炎性因子所致的生理过程失衡等多种因素相关[1]，主要表现为关节软骨的破坏，软骨下骨的吸收以及关节边缘骨赘的形成。正常情况下关节软骨的合成代谢和分解代谢保持着动态的平衡，软骨与软骨下骨处于程度不同的改建过程中，而在骨关节炎中，软骨内这一平衡被打破，软骨细胞减少，软骨基质丧失，软骨变性、脱落。细胞因子在这一过程中起着重要的调节作用。

    1白细胞介素(interleukin，IL)-1

    IL-1作为骨关节炎中主要的炎性因子之一[2] ......