[摘要]近年来，生物陶瓷材料在替代因外伤或疾病而导致缺损的硬组织方面已获得广泛的应用，当材料被植入生物体内后，其表面立即会发生多种蛋白质分子的堆积，这一蛋白质层对于改变材料的表面性质起着重要的作用。因此，对生物材料表面蛋白吸附的考察已经成为评价材料生物相容性和生物活性的重要内容。本文就生物陶瓷表面蛋白吸附的主要种类、研究方法、影响因素及其改进研究等相关内容作一综述，以期为生物陶瓷表面生物学改性的研究提供基础理论参考。

    [关键词]生物陶瓷；蛋白吸附；生物相容性

    [中图分类号]R 783.1[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.04.037

    Research progress of protein adsorption on surface of bioceramicsWang Chuanyong, Li Wei, Jiang Li.(State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China)

    [Abstract]Bioactive ceramics have been widely used in replacing defected hard tissues caused by trauma or disease. When biomaterials are placed in bio-enviroments, various protein molecules will immediately accumulate on material surfaces forming a bioactive layer. Moreover, this protein layer plays an important role in determining the biocompatibility of materials. So this paper briefly reviews the protein adsorption on bioceramics surfaces, including the type of proteins absorbed, methods being used, factors effecting adsorption capacity and methods improving it, providing reference for the surface biological modification of bioactive ceramic materials. ......