蔡 宇

    幽门螺杆菌和非甾体类抗炎药与消化性溃疡发病的相关性分析

    蔡 宇

    目的 探讨幽门螺杆菌(Hp)和非甾体抗炎药(NSAIDs)与消化性溃疡发病的相关性。方法 回顾性选取2012年1月至2015年6月阜新矿业集团总医院收治的101例消化性溃疡患者资料作为观察组，根据发病部位将其分为胃溃疡组(39例)和十二指肠溃疡组(62例)，另选取同时期本院消化内科收治的非消化性溃疡患者120例作为对照组。采用单因素及多因素分析法分析 Hp感染、服用 NSAIDs单独或共同作用对消化性溃疡发病及出血的影响。结果 Hp感染、服用NSAIDs均会增加消化性溃疡发生风险，其中Hp感染会显著增加十二指肠溃疡发生风险；Hp感染合并服用NSAIDs可明显增加胃溃疡、十二指肠溃疡发生风险，单纯Hp感染患者十二指肠溃疡发生风险显著增加；Hp感染合并服用NSAIDs会明显增加胃溃疡合并上消化道出血的风险。结论 Hp感染、服用NSAIDs会显著增加消化性溃疡发生风险，且两者具有协同致病作用；Hp感染同时服用NSAIDs会显著增加胃溃疡并发上消化道出血的风险。

    幽门螺杆菌；非甾体类抗炎药；消化性溃疡；相关性

    【Abstract】Objective To investigate the relationship between Helicobacter pylori (Hp) and non steroidal antiinflammatory drugs(NSAIDs) and peptic ulcer disease.Methods Select the 2012 January 2015 June Fuxin MiningGroup General Hospital from 101 cases of digestive ulcer patients as the observation group，according to the diseased parts of the its for gastric ulcer group(39 cases) and duodenal ulcer group(62 cases)，select the same period in our hospital gastroenterology were non elimination of ulcer in patients with 120 cases as the control group.Single factor and multi factor analysis method was used to analyze the effect of Hp infection and taking NSAIDs alone or together on the incidence and bleeding of peptic ulcer.Results Hp infection and NSAIDs may increase the risk of peptic ulcers occur ......