补中益气汤联合酒石酸托特罗定治疗女性压力性尿失禁的疗效观察(1)

http://www.100md.com 2017年2月15日 《世界中医药》 20174

     摘要目的：观察补中益气汤联合酒石酸托特罗定治疗女性压力性尿失禁(SUI)的临床疗效。方法：将80例SUI患者采用数字随机法分为2组，即对照组和治疗组，每组40例患者。对照组给予酒石酸托特罗定治疗。治疗组在对照组基础上加用补中益气汤。疗程3个月，比较2组总有效率和失禁频率、失禁程度、夜尿次数、ICIQSF评分以及IQOL评分。结果：治疗组总有效率达875%，对照组为625%，治疗组总有效率优于对照组(P<005)。治疗组治疗后失禁频率、失禁程度、夜尿次数、ICIQSF评分、IQOL评分均较治疗前比较有统计学意义(P<005)；而对照组治疗后仅在ICIQSF评分、失禁程度较治疗前比较有统计学意义(P<005)，2组治疗后比较，治疗组各项指标均优于对照组(P<005)。结论：补中益气汤联合酒石酸托特罗定可明显改善SUI患者临床症状，提高生活质量，疗效显著。

    关键词补中益气汤；女性压力性尿失禁；临床疗效

    AbstractObjective：To observe the clinical effiacy of Buzhongyiqi decoction combined with tolterodine tartrate on female patients with stress urinary incontinence (SUI).Methods：Eighty SUI patients were randomly divided into a treatment group and a control group with 40 cases in each.The control group was administered tolterodine tartrate.The treatment group was added with extra Buzhongyiqi decoction on the basis of therapy in the control group.Both groups were observed for 3 months，and incontinence frequency，incontinence degree，the urination frequency at night the ICIQSF and IQOL values were compared.Results：The total effective rate in treatment group was 875%，while the control group 625%，The total effective rate in treatment was better than that in the control group.Comparison between the incontinence frequency，incontinence degree，the urination frequency at night the ICIQSF and IQOL values before and after treatment in the treatment group were significantly different (P<005)；in the control group，only the incontinence degree and ICIQSF values changes had statistical significance (P<005).After treatment，the indicators of the treatment group were all better than those of the control group (P<005).Conclusion：Buzhongyiqi decoction combined with tolterodine tartrate could improve the clinical efficacy of SUI and patient′s life quality.

    Key WordsBuzhongyiqi decoction； Stress urinary incontinence； Tolterodine tartrate

    中圖分类号：R259；R242文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.04.018

    压力性尿失禁(Stress Urinary Incontinence，SUI)是中老年妇女较为常见的疾病，是指在正常情况下无遗尿发生，而腹压增加时，如咳嗽、喷嚏或者活动时，可出现不自主自尿道外口溢出尿液[12]。据报道，我国成年妇女约309%患有尿失禁，其中SUI比例约占61%[34]。SUI严重影响患者的生活质量，目前，在对SUI患者的治疗上，多采用药物、物理、手术等方法，但远期疗效均不理想，有部分患者后期复发。我科长期采用中医经典方剂“补中益气汤”联合酒石酸托特罗定治疗本病，疗效显著，现报道如下。

    1资料与方法

    11一般资料所观察病例来自上海中医药大学附属曙光医院2014年6月至2015年12月的门诊SUI患者，总计80例，按随机数字表法分为治疗组和对照组，每组40例。治疗组平均年龄为(5608±815)岁，平均病程为68个月，其中轻度尿失禁25例，中度尿失禁15例；对照组平均年龄(5723±901)岁，平均病程为70个月，轻度尿失禁22例，中度尿失禁18例。其中轻度尿失禁定义为治疗前1 h尿垫试验漏尿量为10～99 g，中度尿失禁定义为治疗前1 h尿垫试验漏尿量为100～499 g。2组患者的平均年龄、病程及尿失禁程度比较均无统计学意义(P>005)，具有可比性。(丁毅 赵建华 翟新宇)

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