益气补肾止喘汤联合西药对小儿哮喘的疗效观察及对血清ET—1、NO、CEC水平的影响(1)

http://www.100md.com 2017年4月15日 《世界中医药》 20178

     摘要 目的：探讨益气补肾止喘汤联合西药对小儿哮喘的疗效及对血清ET-1、NO、CEC水平的影响。方法：选取2014年1月至2015年9月郑州市第一人民医院收治的小儿支气管哮喘患者158例，隨机分为对照组和观察组，每组79例。对照组给予常规西药治疗，观察组在对照组的基础上联用益气补肾止喘汤，2组均连续治疗3个月。统计2组临床总有效率；比较2组治疗前后肺功能指标及血清ET-1、NO、CEC水平的变化；治疗后随访1年，比较2组哮喘发作情况。结果：观察组临床总有效率96.20%，显著高于对照组的75.95%，差异有统计学意义(P<0.01)；与治疗前比较，治疗后2组FVC、FEV1、FEV1/FVC、MMEF及PEF均显著增大，而血清ET-1、NO及CEC水平显著降低，且2组间上述各指标均，差异有统计学意义(P<0.05或P<0.01)；随访显示，观察组患儿呼吸道感染次数、哮喘发作次数均较对照组患儿显著降低，哮喘发作持续时间显著缩短，差异有统计学意义(P<0.01)。结论：益气补肾止喘汤联合西药治疗小儿哮喘，可显著降低ET-1、NO、CEC表达水平，减轻气道损伤，同时可改善患者肺功能并减少哮喘复发，疗效显著优于常规西药单用。

    关键词 哮喘；益气补肾止喘汤；肺功能；ET-1；NO；CEC

    Observation on Clinical efficacy of Yiqi Bushen Zhichuan Decoction Combined with Western Medicine for Infantile Asthma and Its Effects on Serum ET-1， NO， CEC

    Jia Ru， Zhang Yaqin， Zhu Wei， Zhao Lan

    (The First People′S Hospital of Zhengzhou， Zhengzhou 450000， China)

    Abstract Objective：To explore the clinical efficacy of Yiqi Bushen Zhichuan Decoction combined with western medicine in treating infantile asthma and its effects on serum ET-1， NO， CEC levels.Methods：A total of 158 cases children with asthma were divided into control group and observation group， with 79 cases in each group. The control group was treated with conventional western medicine， while the observation group was additionally treated with Yiqi Bushen Zhichuan Decoction. Patients in the two groups were all treated for 3 months. The clinical efficient of the two groups were calculated； the changes of lung function indexes and serum ET-1， NO， CEC levels in two groups before and after treatment were compared； the recurrence of asthma were compared after 1-year followed-up after the treatment.Results：The clinical total effective rate of observation group was 96.20%， which was higher than that 75.95% of control group (P<0.01). The FVC， FEV1， FEV1/FVC， MMEF and PEF increased significantly after the treatment， and the serum ET-1， NO and CEC levels decreased significantly， which both showed significant difference between the two groups (P<0.05 orP<0.01). The following-up showed that times of the respiratory tract infection and the recurrence of asthma decreased compared with those of the control group and the duration time of asthma shortened significantly (P<0.01).Conclusion：Yiqi Bushen Zhichuan Decoction combined with western medicine can reduce the expression levels of serum ET-1， NO and CEC of children with asthma， reduce airway damage， improve the lung function， and decrease the recurrence of asthma. Its clinical efficacy is superior to the conventional western medicine treatment.(贾铷 张雅琴 祝伟 赵岚)

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