黄连降糖汤治疗2型糖尿病的临床疗效及对血管VEGF的影响分析(1)
摘要 目的：分析黄连降糖汤治疗2型糖尿病的临床疗效及对血管VEGF的影响。方法：选取2015年1月至2016年12月张家港市中医医院确诊治疗的2型糖尿病患者80例，按照随机数字表法随机分为对照组和观察组，每组40例。对照组服用盐酸二甲双胍肠溶胶囊治疗，观察组服用黄连降糖汤治疗，2组均治疗2个月。观察2组患者的临床疗效、血糖血脂指标包括空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1C)、血脂总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平。检测治疗前后VEGF水平变化情况。结果：观察组总有效率为90.00%；对照组总有效率为72.50%。经过治疗后，患者的FPG、2 h PBG、HbA1c、TC、TG、LDL-C水平均呈现降低趋势，HDL-C水平则明显增加。观察组的血糖血脂水平明显优于对照组(P<0.05)。观察组治疗后VEGF水平为(118.52±21.20)ng/L，对照组为(140.26±27.67)ng/L；观察组明显低于对照组(P<0.05)。结论：黄连降糖汤治疗2型糖尿病安全有效，能够降低血管VEGF水平来减小对内皮细胞的损伤，标本兼顾，值得临床推广。
, 百拇医药
关键词 2型糖尿病；黄连降糖汤；血管VEGF
Abstract Objective：To analyze the clinical effect of Huanglian Jiangtang Decoction on the treatment of type 2 diabetes mellitus and its effect on the vascular VEGF. Methods：A total of 80 patients who were diagnosed as type 2 diabetes mellitus patients from January 2015 to December 2016 in the hospital were included and randomly divided into two groups. Patients in the control group took metformin hydrochloride enteric-coated capsules， while patients in the observation group received Huanglian Jiangtang Decoction. Patients in the two groups were treated for 2 successive months. The clinical efficacy and blood glucose and blood lipid indexes， including fasting blood glucose (FPG)， 2 hour postprandial blood glucose (2 hPBG)， glycosylated hemoglobin (HbA1C)， total cholesterol (TC)， triglyceride (TG)， low density lipoprotein (LDL-C)， high density lipoprotein (HDL-C) level were observed. Changes in VEGF levels were observed before and after the treatment in the two groups. Results：The total effective rate of observation group was 90%， and the total effective rate of control group was 72.50%. After treatment， the patients′ FPG， 2 hPBG， HbA1c， TC， TG， LDL-C levels were all showed a decreasing trend， and the HDL-C level was significantly increased. The blood glucose and blood lipid levels in the observation group were significantly better than those in the control group (P<0.05). After treatment， the VEGF level of the observation group was (118.52±21.20) ng/L， the control group was (140.26±27.67) ng/L； the observation group was significantly lower than the control group (P<0.05). Conclusion：Huanglian Jiangtang Decoction is safe and effective in the treatment of type 2 diabetes. It can reduce the vascular VEGF level to prevent damages to endothelial cells in certain degree， which is worthy of clinical application.
Key Words Huanglian Jiangtang Decoction； Type 2 diabetes mellitus； Vascular VEGF
中圖分类号：R255.4文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.10.012, 百拇医药(沈小璇 李亚娟)
, 百拇医药
关键词 2型糖尿病；黄连降糖汤；血管VEGF
Abstract Objective：To analyze the clinical effect of Huanglian Jiangtang Decoction on the treatment of type 2 diabetes mellitus and its effect on the vascular VEGF. Methods：A total of 80 patients who were diagnosed as type 2 diabetes mellitus patients from January 2015 to December 2016 in the hospital were included and randomly divided into two groups. Patients in the control group took metformin hydrochloride enteric-coated capsules， while patients in the observation group received Huanglian Jiangtang Decoction. Patients in the two groups were treated for 2 successive months. The clinical efficacy and blood glucose and blood lipid indexes， including fasting blood glucose (FPG)， 2 hour postprandial blood glucose (2 hPBG)， glycosylated hemoglobin (HbA1C)， total cholesterol (TC)， triglyceride (TG)， low density lipoprotein (LDL-C)， high density lipoprotein (HDL-C) level were observed. Changes in VEGF levels were observed before and after the treatment in the two groups. Results：The total effective rate of observation group was 90%， and the total effective rate of control group was 72.50%. After treatment， the patients′ FPG， 2 hPBG， HbA1c， TC， TG， LDL-C levels were all showed a decreasing trend， and the HDL-C level was significantly increased. The blood glucose and blood lipid levels in the observation group were significantly better than those in the control group (P<0.05). After treatment， the VEGF level of the observation group was (118.52±21.20) ng/L， the control group was (140.26±27.67) ng/L； the observation group was significantly lower than the control group (P<0.05). Conclusion：Huanglian Jiangtang Decoction is safe and effective in the treatment of type 2 diabetes. It can reduce the vascular VEGF level to prevent damages to endothelial cells in certain degree， which is worthy of clinical application.
Key Words Huanglian Jiangtang Decoction； Type 2 diabetes mellitus； Vascular VEGF
中圖分类号：R255.4文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.10.012, 百拇医药(沈小璇 李亚娟)
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