中药质量源于设计方法和应用：连续制造(8)
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, 百拇医药
[33]Zhang P，Russell MG，Jamison TF.Continuous Flow Total Synthesis of Rufinamide[J].Organic Process Research & Development，2014，18(11)：1567-1570.
[34]Ghislieri D，Gilmore K，Seeberger PH.Chemical assembly systems：layered control for divergent，continuous，multistep syntheses of active pharmaceutic-al ingredients[J].Angewandte Chemie International Edition，2015，54(2)：678-682.
[35]Correia CA，Gilmore K，Mcquade DT，et al.A Concise Flow Synthesis of Efavirenz[J].Angewandte Chemie International Edition，2015，54(16)：4945-4948.
, 百拇医药
[36]Heider PL，Born SC，Basak S，et al.Development of a Multi-Step Syn-thesis and Workup Sequence for an Integrated，Continuous Manufacturing Process of a Pharmaceutical[J].Organic Process Research&Development，2014(41)：762-765.
[37]Jolliffe HG，Gerogiorgis DI.Process modelling，simulation and technoe-conomic evaluation of separation solvents for the Continuous Pharmaceutical M-anufacturing (CPM) of diphenhydramine[J].Chemical Engineering Research and Desig-n，2016(112)：310-325.
, 百拇医药
[38]Lin H，Dai C，Jamison TF，et al.A Rapid Total Synthesis of Ciprofloxa-cin Hydrochloride in Continuous Flow[J].Angewandte Chemie International Ed-ition，2017，56(30)：8870-8873.
[39]Yang X，Acevedo D，Mohammad A，et al.Risk Considerations on Devel-oping a Continuous Crystallization System for Carbamazepine[J].Organic Process Research & Development，2017，21(7)：1021-1033.
[40]Jain I H，Zazzeron L，Goli R，et al.Hypoxia as a therapy for mitochond-rial disease[J].Science，2016，352(6281)：54-61.
, 百拇医药
[41]Miotto M，Gouveia R，Abidin F Z，et al.Developing a Continuous Biopr-ocessing Approach to Stromal Cell Manufacture[J].ACS Applied Materials&I-nterfaces，2017，9(47)：41131-41142.
[42]Burgbacher J，Wiss J.Industrial Applications of Online Monitoring of Dry-ing Processes of Drug Substances Using NIR[J].Organic Process Research & Development，2008，12(2)：235-242.
[43]Chablani L，Taylor MK，Mehrotra A，et al.Inline real-time near-infrared granule moisture measurements of a continuous granulation-drying-milling proc-ess[J].Aaps Pharmscitech，2011，12(4)：1050-1055.
[44]Vanarase A U，Alcalà M，Rozo J I J，et al.Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy[J].Chemical Engineering Science，2010，65(21)：5728-5733., 百拇医药(王芬 徐冰 刘雨 李建宇 史新元 乔延江)
[31]Lévesque F，Seeberger PH.Continuous-flow synthesis of the antimalaria drug artemisinin[J].Angewandte Chemie International Edition，2012，51(7)：1706.
[32]Deadman BJ，Hopkin MD，Baxendale IR，et al.ChemInform Abstract：T-he Synthesis of BcrAbl Inhibiting Anticancer Pharmaceutical Agents Imatinib，Nilotinib and Dasatinib[J].Organic & Biomolecular Chemistry，2013，11(11)：1766-1800.
, 百拇医药
[33]Zhang P，Russell MG，Jamison TF.Continuous Flow Total Synthesis of Rufinamide[J].Organic Process Research & Development，2014，18(11)：1567-1570.
[34]Ghislieri D，Gilmore K，Seeberger PH.Chemical assembly systems：layered control for divergent，continuous，multistep syntheses of active pharmaceutic-al ingredients[J].Angewandte Chemie International Edition，2015，54(2)：678-682.
[35]Correia CA，Gilmore K，Mcquade DT，et al.A Concise Flow Synthesis of Efavirenz[J].Angewandte Chemie International Edition，2015，54(16)：4945-4948.
, 百拇医药
[36]Heider PL，Born SC，Basak S，et al.Development of a Multi-Step Syn-thesis and Workup Sequence for an Integrated，Continuous Manufacturing Process of a Pharmaceutical[J].Organic Process Research&Development，2014(41)：762-765.
[37]Jolliffe HG，Gerogiorgis DI.Process modelling，simulation and technoe-conomic evaluation of separation solvents for the Continuous Pharmaceutical M-anufacturing (CPM) of diphenhydramine[J].Chemical Engineering Research and Desig-n，2016(112)：310-325.
, 百拇医药
[38]Lin H，Dai C，Jamison TF，et al.A Rapid Total Synthesis of Ciprofloxa-cin Hydrochloride in Continuous Flow[J].Angewandte Chemie International Ed-ition，2017，56(30)：8870-8873.
[39]Yang X，Acevedo D，Mohammad A，et al.Risk Considerations on Devel-oping a Continuous Crystallization System for Carbamazepine[J].Organic Process Research & Development，2017，21(7)：1021-1033.
[40]Jain I H，Zazzeron L，Goli R，et al.Hypoxia as a therapy for mitochond-rial disease[J].Science，2016，352(6281)：54-61.
, 百拇医药
[41]Miotto M，Gouveia R，Abidin F Z，et al.Developing a Continuous Biopr-ocessing Approach to Stromal Cell Manufacture[J].ACS Applied Materials&I-nterfaces，2017，9(47)：41131-41142.
[42]Burgbacher J，Wiss J.Industrial Applications of Online Monitoring of Dry-ing Processes of Drug Substances Using NIR[J].Organic Process Research & Development，2008，12(2)：235-242.
[43]Chablani L，Taylor MK，Mehrotra A，et al.Inline real-time near-infrared granule moisture measurements of a continuous granulation-drying-milling proc-ess[J].Aaps Pharmscitech，2011，12(4)：1050-1055.
[44]Vanarase A U，Alcalà M，Rozo J I J，et al.Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy[J].Chemical Engineering Science，2010，65(21)：5728-5733., 百拇医药(王芬 徐冰 刘雨 李建宇 史新元 乔延江)