补中益气汤对便秘型肠易激综合征血液学及肠敏感度的影响(1)
摘要 目的：觀察方药补中益气汤在治疗便秘型肠易激综合征的临床疗效，并分析其对患者相关指标的影响。方法：选取2016年1月至2016年12月武汉市中西医结合医院消化内科门诊及住院的便秘型肠易激综合征患者90例，通过随机数字法随机分为观察组和对照组，每组45例。在基础治疗的同时，对照组予以双歧杆菌三联活菌胶囊口服，观察组加补中益气汤口服，2组均治疗8周。治疗前后抽取血液测定血清内P物质(Substance P)、血浆生长抑素(Somatostatin，SS)，神经肽Y(Neuropeptide Y，NPY)。通过肠镜下取结肠黏膜组织，运用荧光定量PCR测定其蛋白酶激活受体-2水平，同时进行肠敏感度的评定及临床疗效分析。结果：治疗后观察组总有效率(88.89%)优于对照组(77.78%)(P<0.05)。2组肠道敏感度均较治疗前明显改善(P<0.05)，且观察组腹痛、腹胀、腹泻评分改善程度明显优于对照组(P<0.05)。同时治疗后2组患者的血清SP、SS水平及肠黏膜PAR-2表达均降低，而血清NPY水平升高，且观察组改善程度优于对照组(P<0.05)结论：脾胃虚弱证便秘型肠易激综合征患者口服补中益气汤可以有效的改善其临床症状。
, 百拇医药
关键词 补中益气汤；便秘型；肠易激综合征；肠敏感度；血清内P物质；血浆生长抑素；神经肽Y；蛋白酶激活受体-2
Abstract Objective：To observe the clinical effects of Buzhong Yiqi decoction in the treatment of constipation predominant irritable bowel syndrome.Methods：A total of 90 patients with constipation predominant irritable bowel syndrome (IBS) admitted in our hospital from January 2016 to December 2016 were selected and divided into treatment group and control group by random number table， with 45 cases in each group.The control group was given Bifidobacterium triple viable capsules orally， and the treatment group was treated with oral administration of Buzhong Yiqi Decoction.Both groups were treated for 8 weeks.Blood samples were collected before and after treatment to determine the substance P， plasma somatostatin (SS)， neuropeptide Y (NPY).The colonic mucosal tissue was obtained by colonoscopy， and the content of protease activated receptor-2 was determined by fluorescence quantitative PCR.Results：After treatment， the total effective rate of the treatment group (88.89%) was better than that of the control group (77.78%) (P<0.05).The intestinal sensitivity of two groups were significantly improved compared before treatment (P<0.05)， and the improvement of abdominal pain， abdominal distension， diarrhea score in the treatment group was significantly better than the control group (P<0.05).The serum SP content and intestinal mucosa SS expression of PAR-2 were decreased after treatment at the same time， and the level of serum NPY increased.The improvement of the treatment group was better than the control group (P<0.05).Conclusion：The treatment of Buzhong Yiqi decoction in spleen and stomach deficiency constipation irritable bowel syndrome patients can effectively improve the clinical symptoms， which is worthy of clinical use.
Key Words Buzhong Yiqi Decoction； Constipation type； Irritable bowel syndrome； Intestinal sensitivity； Substance P； Somatostatin； Neuropeptide； Protease activated receptor-2, 百拇医药(石亮 杨健 徐丹)
, 百拇医药
关键词 补中益气汤；便秘型；肠易激综合征；肠敏感度；血清内P物质；血浆生长抑素；神经肽Y；蛋白酶激活受体-2
Abstract Objective：To observe the clinical effects of Buzhong Yiqi decoction in the treatment of constipation predominant irritable bowel syndrome.Methods：A total of 90 patients with constipation predominant irritable bowel syndrome (IBS) admitted in our hospital from January 2016 to December 2016 were selected and divided into treatment group and control group by random number table， with 45 cases in each group.The control group was given Bifidobacterium triple viable capsules orally， and the treatment group was treated with oral administration of Buzhong Yiqi Decoction.Both groups were treated for 8 weeks.Blood samples were collected before and after treatment to determine the substance P， plasma somatostatin (SS)， neuropeptide Y (NPY).The colonic mucosal tissue was obtained by colonoscopy， and the content of protease activated receptor-2 was determined by fluorescence quantitative PCR.Results：After treatment， the total effective rate of the treatment group (88.89%) was better than that of the control group (77.78%) (P<0.05).The intestinal sensitivity of two groups were significantly improved compared before treatment (P<0.05)， and the improvement of abdominal pain， abdominal distension， diarrhea score in the treatment group was significantly better than the control group (P<0.05).The serum SP content and intestinal mucosa SS expression of PAR-2 were decreased after treatment at the same time， and the level of serum NPY increased.The improvement of the treatment group was better than the control group (P<0.05).Conclusion：The treatment of Buzhong Yiqi decoction in spleen and stomach deficiency constipation irritable bowel syndrome patients can effectively improve the clinical symptoms， which is worthy of clinical use.
Key Words Buzhong Yiqi Decoction； Constipation type； Irritable bowel syndrome； Intestinal sensitivity； Substance P； Somatostatin； Neuropeptide； Protease activated receptor-2, 百拇医药(石亮 杨健 徐丹)
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