王红娟 王芳 王亚桃

    摘要 目的：为了得到苍耳子油脂质体的最佳制备工艺。方法：以卵磷脂和胆固醇为膜材，采用薄膜分散水化法制备脂质体，利用游离药物与含药脂质体的重量差异通过超速离心法分离，并计算其包封率。根据单因素实验得对其包封率有显著影响的因素，以正交试验设计筛选出制备脂质体的最佳制备方法。结果：通过正交试验得到最优方法为：卵磷脂：胆固醇3∶1、苍耳子油：卵磷脂1∶7、水化溶液体积20 mL，此条件下测得其包封率为68.0%。结论：该方法所得脂质体包封率达60%以上，比较稳定。

    关键词 苍耳子油;脂质体;包封率;正交试验

    Study on Preparation Technology of Xanthii Fructus Oil Liposomes

    WANG Hongjuan，WANG Fang，WANG Yatao

    (Gansu Medical College，Pingliang 744000，China)

    Abstract Objective：In order to obtain the optimal preparation process of Xanthii Fructus oil liposomes.Methods：Lecithin and cholesterol was used as membrane materials，liposomes were prepared by a thin film dispersion hydration method.The weight difference between free drugs and drug-containing liposomes was used to separate them by ultracentrifugation ......